Cross-Linking of Hyaluronan into a Three-Dimensional Network

2 Cross-Linking of Hyaluronan into a Three-Dimensional Network 

In cross-linking HA with bi-functional reagents like BDDE or DVS, first an aqueous solution of hyaluronan is prepared, into which the given quantity of the cross-linking agent 

Let us discuss this in further detail. Elasticity is the ability of material to restore its initial form alter removal of stress exerted by external forces. When the form is restored completely, the material is called elastic. The polymeric materials that possess elastic properties can be divided into two groups. The first group includes materials that manifest very strong resistance to a change in the form and are reversibly deformable to an extent. The second group includes polymers that easily change their form and are capable to be 

In the statistical theory of elasticity for spatially structured polymers, the modulus of elasticity is a function of the number of effective cross-links  

The network density or the number of cross-links is determined either as Me or molar concentration of the chain fragments between two cross-links (v) in the unit of volume (V)  

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