Cross-linking effect biomaterials

Lin F H, Yao C H, Sun J S (1998), Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde cross-linked gelatine . Biomaterials, 19, 905-17. 

Lee, C. R., Grodzinsky, A. J., and Pector, M. (2001). The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis. Biomaterials 22,3145-3154. 

Milthorpe,B.K. Schindhelm,K. Roe,S. Effect of glutalardehyde concentration on collagen cross-linking and absorption Heimke,G. Soltesz,U. Lee,A.J.C., eds. Advance in Biomateri s, 9 Elsevier Science Publishers B.V., Amsterdam, 1990,1-5. 

Oral E, Beckos CG, Malhi AS, Muratoglu OK (2008), The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene . Biomaterials, 29, 3557-3560, DOl 10.1016/j.biomaterials.2008.05.004. 

After implantation as dural substitute, collagen gradually degrades and cells synthesize their own dura mater. The non-degradable PET mesh remains in organism as unnecessary ballast. It is very important that collagen biomaterials can be effectively cross-linked and simultaneously sterilized by radiation technique, which does not produce toxic by-products detrimental to wound healing. 

Zhu, Y, Hu, J. L., Yeung, Y. (2009b), Effect of soft-segment crystallization, hard segment physical cross-link on shape memory function in antibacterial segmented PU ionomers, Acta Biomaterials, 5, 3346-57. 

Scotchford, C.A., Cascone, M.G., Downes, S., and Giusti, P. (1998) Osteoblast responses to collagen-PVA bioartificial polymers in vitro the effects of cross-linking method and collagen content. Biomaterials, 19,... 

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