Cross docking

Cross Docking is a process where pallet lots of products arriving at a distribution centre are broken up by individual products and sorted into palletized store orders or consolidated to make full tmck loads. Next, the reassembled pallets are loaded onto trucks for delivery to stores. The products never go into storage because they are placed in shipping trucks, soon after they are unloaded from arriving trucks and consolidated. The benefits from cross docking include rapid fulfillment of customer orders, reduced inventory, increased flow of goods, and reduced consolidation effort by suppliers. 

Wal-Mart- The world s largest retailer, delivers about 85% of its merchandise through a cross-docking system. Home Depot serves more than 100 stores in the Northeast US through a cross dock (Bartholdi and Gue 2004). Each store may place orders with many vendors who send truckloads of products to Home Depot s cross dock. The products are consolidated into store-specific truck loads bound for individual stores. If the number of vendors exceeds the number of stores supplied, the number of receiving doors (bays) at the cross dock would exceed the number of shipping doors. Transportation cost is reduced because of the FTL shipments. 

Toyota uses cross docking to directly feed components to its assembly lines. It places JIT orders with its suppliers, who deliver the components to a cross dock managed by a third party logistics service provider. The 3PL sorts the components and configures them as pallet loads, as per demand of specific assembly lines and delivers them just in time. 

Many retail chains negotiate with their vendors to have the vendors prepare the product for cross-docking before shipping it to the retailer s distribution center. This is known as pre allocation or pre distribution. The supplier would be expected to label products by the destination store for automatic sorting upon arrival at the retailer s DC. As an example, consider a supplier producing three products - A, B, and C - supplying five stores of a retailer. The supplier would stack five units of 

At the buyer s cross dock, the units of the products will be sorted on five store-specific pallets as shown in Fig. 5.5. The retailer then loads the store-specific pallets on trucks bound for the specific stores. Alternatively, the supplier may be required to sort and palletize cartons for each of the retailer s stores, as in Fig. 5.5, for quick and easy cross-docking. It follows that the supplier would need additional effort, manpower, technology, and expertise, to sort the products. In addition, the supplier would need more detailed demand information - which stores need how many units of each product. 

In all the methods discussed above, the docking procedirre involved docking of ligands to the native conformation of protein termed as self-docking. There is another 

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MRC Docking Single Conformer Cross Docking 4D Docking... 

Fig. 8. The accuracy of the ligand binding pose prediction for different ensemble sizes. The tors reflect the fraction of the ligands that dock correctly using traditional ensemble docking and 4D docking for varying ensemble size, compared to the accuracy of a single-receptor cross-docking.

Table4.1 Protein kinase A cross-docking results for rigid and flexible receptor docking (side chain of PHE327 flexible).

R. (2009) Consistent improvement of cross-docking results using binding site ensembles generated with elastic network normal modes. Journal of Chemical Information and Modeling, 49, 716-725. 

Sotriffer, C.A. and Dramburg, I. (2005) In situ cross-docking to simultaneously address multiple targets. Journal of Medicinal Chemistry, 48 (9), 3122—3125. 

May, A. and Zacharias, M. (2008) Protein-ligand docking accounting for receptor side chain and global flexibility in normal modes evaluation on kinase inhibitor cross docking. Journal of Medicinal Chemistry, 51 (12), 3499-3506. 

The impact of receptor flexibility on docking is usually assessed by cross-docking experiments, whereby a series of ligands is docked to all their corresponding... 

Daeyaert, F., de Jonge, M., Heeres, J., Koymans, L., Lewi, P., Vinkers, M.H., and Janssen, P.A. (2004) A pharmacophore docking algorithm and its application to the cross-docking of 18 HlV-NNRTTs in their binding pockets. Proteins, 54, 526-533. 

Duca, J.S., Madison, V.S., and Voigt, J.H. (2008) Cross-docking of inhibitors into CDK2 structures. 1. Journal of Chemical Information and Modeling, 48, 659-668. 

Given the complexity of the warehouse, it is easy to see how systems and technologies can be of considerable benefit. An effective warehouse-management system saves labor costs, improves inventory management by reducing inaccuracies, speeds delivery of merchandise to store or consumer, and enhances cross-docking management. 

Cross-docking of merchandise occurs when the delivery of product to the distribution center is put directly into the trucks heading for the stores. For cross-docking to work well, suppliers and retailers must have fuUy integrated information systems. For example. Federal Express manages the complex task of getting all the component parts to Dell at the same time so that a particular DeU Computer order can be manufactured without Dell having to have inventories on hand. 

Greater and more effective adoption of quick response. More frequent dehvery of less. Greater use of cross-docking so that merchandise hits the docks of the thstribution centers and is immediately loaded into destination trucks. EDI and POS electronics will track what is selling and transmit directly to distribution center to plan shipment. 

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