Cromoglycate absorption

Wilson, C. G. Tomlinson, E. Davis, S. S. Olejnik, O., Altered ocular absorption and disposition of sodium cromoglycate upon ion-pair and complex coacervate formation with dodecylbenzyldimethyl-ammonium chloride, J. Pharm. Pharmacol. 31, 749-753 (1981). 

Saturable carrier-transport mechanisms have also been identified for organic anions such as sodium cromoglycate but the contribution of these mechanisms to the overall absorption of these compounds after therapeutic dosing is not known. 

Yoshimi, A. Hashizume, H. Kitagawa, M. Nishimura, K. Kakeya, N. Characteristics of l,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)-lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits. J.Pharmacobiodyn., 1992, 15, 681—686... 

There are many possible reasons for the non-appearance to date of successors to cromoglycate and it could be that there is a different reason or set of reasons for each individual compound. Problems of absorption, transport, distribution or metabolism may play more or less important roles in different cases. It may be that inhibition of mediator release is not the most important factor in the clinical effectiveness of cromoglycate. Most of the effort devoted to antiallergic research has assumed that inhibition of mediator release was the sole requirement of an effective prophylactic drug for allergic asthma. Only the next... 

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