Creutzfeldt human risk

Albumin (human) Epoetin alfa contains albumin, a derivative of human blood. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral diseases. No cases of transmission of viral diseases or Creutzfeldt-Jakob disease have ever been identified for albumin. Anemia Not intended for CRF patients who require correction of severe anemia epoetin alfa may obviate the need for maintenance transfusions but is not a substitute for emergency transfusion. Not indicated for treatment of anemia in HIV-infected patients or cancer patients due to other factors such as iron or folate deficiencies, hemolysis, or Gl bleeding, which should be managed appropriately. Hypertension Up to 80% of patients with CRF have a history of hypertension. Do not treat patients with uncontrolled hypertension monitor blood pressure adequately before initiation of therapy. Hypertensive encephalopathy and seizures have occurred in patients with CRF treated with epoetin. 

Albumin (human) Darbepoetin formulated with albumin carries an extremely remote risk for transmission of viral diseases. A theoretical risk for transmission of Creutzfeldt-Jakob disease (CJD) also is considered extremely remote. No cases of transmission of viral disease or CJD have ever been identified for albumin. Pregnancy Category C. 

TWo formulations available, one containing polysorbate 80, the other containing human albumin a theoretical risk for Creutzfeldt-Jakob disease exists with the albumin formulation but is considered extremely remote... 

CPMP report. Risk of transmission of Creutzfeldt-Jakob disease via medicinal products derived from human blood or plasma. CPMP report 1995 846/95. 

Prions (small proteinaceous infectious particles) are a unique class of infectious agent causing spongiform encephalopathies such as bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans. There is considerable concern about the transmission of these agents from infected animals or patients. Risk of infec-tivity is highest in brain, spinal cord and eye tissues. There are still many unknown factors regarding de-... 

Somatotropin (growth hormone GH) is a pituitary somatotrophic linear peptide hormone of 191 residues. The name somatotropin is used for human growth hormone (HGH), which was isolated from the pituitary glands of cadavers. This when used to treat short stature (dwarfism) brought with it the risk of acquiring Creutzfeldt-Jakob disease through contamination. It is now replaced in many countries by somatropin, which is a biosynthetic form of human growth hormone without this liability. 

Lucker, E., Horlacher, S., and Eigenbrodt, E. 2001. Brain in human nutrition and variant Creutzfeldt—Jakob disease risk (vCJD) Detection of brain in retail liver sausages using cholesterol and neuron specific enolase. Br. ]. Nutr. 86, S115-S119. 

Patients with emphysema that is assooiated with ATT deficiencies can receive weekly IV infusions of to maintain acceptable antiprotease activity that can minimize their disease progression. The three approved ATT produots are Aralast, Prolastin, and Zemaira. Because these protein produots are derived from human plasma, there is the risk of transmission of viral infection and Creutzfeldt-Jakob disease. 

Despite cases of transmission of hepatitis C associated with intravenous immunoglobulin in the 1990s, no cases of transmission of hepatitis, HIV, or Creutzfeldt-Jakob disease have since been reported with immunoglobulins [6 J. Before 1996, PCCs (prothrombin complex concentrates) were associated with minimal risk of transmission of infective agents [7 ]. There are no documented cases of viral transmission in patients with von Willebrand disease or hemophilia A treated with Haemate P/Humate P in over 25 years of clinical experience in Europe and more than 17 years in the USA [ ]. In the IMPACT-1 and IMPACT-2 trial in 124 patients there were no cases of HIV, hepatitis, or human B19 virus conversion. Furthermore, no cases of viral transmission have been reported during 30 years of post-marketing surveillance of Cl-esterase inhibitor concentrate [9, 10 ]. 

Prions The use of bovine thrombin in fibrin sealants increases the risk of transmission of bovine spongiform encephalitis (BSE) [11 ]. However, the risk of transmitting prion diseases by giving human blood or blood products is theoretical at present. Because of the long incubation time it is challenging to evaluate the risk [2 ]. In 168 UK cases of variant Creutzfeldt-Jakob disease (vCJD), nine patients had received fractionated plasma products on 12 occasions, intramuscular immunoglobulins for travel on four occasions Rh(D) immunoglobulin for rhesus... 

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