Creation of Fine Particles—In-Line Reactive Crystallization

MSA/EtOAc charge profile Increase in filtration flux 

This example is another illustration of the important effects of seeding and addition rate on reactive crystallization. In the example, the filtration rate of the product crystals is used as a measure of the impact of these critical variables. 

5 CREATION OF FINE PARTICLES-IN-LINE REACTIVE CRYSTALLIZATION 

In-line methods are applicable to reactive crystallization with systems with a relatively fast reaction rate and a short nucleation induction time. There are two in-line devices that have potential for these applications impinging jets and vortex mixers. The reader is referred to Chapter 9 for a discussion of impinging jets as applied to antisoivent crystallization. The application to reactive crystallization is similar—creation of high supersaturation in a 

Impinging jets have been studied experimentally for the reactive crystallization of calcium oxalate by Condon (2001) and Hacherl (Condon) (2003). A primary objective of this study was the detennination of the capability of the jet system to produce fine 

---

Creation of Fine Particles—In-Line Reactive Crystallization 231... 

---