Coumarins sweet woodruff

Coumarin was first isolated by Vogel in 1820 by extraction from tonka beans (Dipteryx odorata). It was subsequently identified in a large number of plants belonging to many different families. Its better known occurrences are in sweet clover (Melilotus alba and M. officinalis), sweet woodruff (Asperula odorata), vanilla leaf (Trilisa odoratissima), vanilla beans (Vanillaplanifolia), cassia (Cinnamorum cassia), lavender (Lavendula officinalis) and balsam of Peru (Myroxylon pereirae) (Perone, 1972 Maries et al, 1987 Boisde Meuly, 1993 Budavari, 1998). 

Coumarin constituents (black cohosh, chamomile, fenugreek, horse chestnut, sweet melilot, tonka beans, sweet woodruff). Naturally occurring coumarins are only weakly anticoagulant, but improper storage causes the production of dicoumarol by microbial transformation. Woodruff may contain constituents of warfarin... 

Asperula odorata (sweet woodruff) is rich in coumarins. 

Coumarin is a natural product found at high levels in some essential oils, particularly ciimamon leaf oil (40 600 ppm (mg/kg)), ciimamon bark oil (7000 ppm), other types of cinnamon (900 ppm), cassia leaf oil (17 000-87 300 ppm), peppermint oil (20 ppm), lavender oil, woodruff and sweet clover as well as in green tea (0.2-1.7 ppm), fruits such as bilberry and cloudberry and other foods such as chicory root (Boisde Meuly, 1993 TNO, 1996 Lake, 1999). It is also found in Mexican vanilla extracts (Sullivan, 1981 Maries etal, 1987). 

Coumarin occurs in lavender, woodruff [Asperula), tonka beans, and sweet clover (Melilotus). Coumarin can be extracted from sweet clover with hot water. Reference (Sethna 1945)... 

Coumarin is found in a large number of plants belonging to many different families including tonka beans, woodruff, lavender oil, cassia, melilot (sweet clover), and other plants. It is found in edible plants such as strawberries, cinnamon, peppermint, green... 

CoUknarin, 2H-1 -Renzopyran-2-one 1,2-benzopyrene cis-o-coumarinic acid lactone cumarin coumarinic anhydride tonka bean camphor. C4H602. mol wt 146.14. C 73-96%, H 4.14%, O 21-90%. In tonka beans, lavender oil, woodruff (Asperuta species), in sweet clover (MeUlotus). Crystal and molecular structure Chem. Commun.. Univ. 

---