Coumarin antifungal property

COUMARINS, THE BIOACIWE STRUCTURES WITH ANTIFUNGAL PROPERTY... 

Coumarins, The Bioactive Structures with Antifungal Property... 

The eco-friendly one-pot three-component reaction of 4-hydroxy-7-methylcoumarin, chalcones 130 and ammonium acetate as a source of ammonia was reported [106] to proceed in PEG 400 affording pyrido[3,2-c]coumarines 131 (Scheme 75). The reaction products demonstrated antibacterial and antifungal properties. 

Several coumarin derivatives have revealed pronounced medicinal value as antibacterial and antifungal agents [57,58]. Others have displayed antituber-cular activity [59] and some have insecticidal properties [60]. This prompted us to investigate the preparation of a new series of compounds containing coumarin moieties with different side chains or fused rings. 

Their application in the biomedical field is clearly demonstrated by the preponderance of patents as compared to publications in the field. Calixarenes functionalized at the wide rim with sulfonic acid and sulfonamide groups showed anticoagulant and antithrombotic properties, approaching the activity of heparin and coumarin, currently used as anticoagulants in antithrombotic therapy. Calixarene derivatives are also active as antiviral, antimicrobial. and antifungal agents. 

In this review we have discussed published results concerning the QSAR research on antimicrobial properties of synthetic and natural compounds. Antifungal and antimicrobial activity of some coumarin derivatives, various types of biological activities of benzamides, several studies on cinnamic acid derivatives with antibacterial and antifungal activity, reports on the biological activity of homoisoflavanones and phenolic compounds, as well as pharmaceutical applications of furan derivatives have been shown. 

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