Coscinoderma

Suvanine (358), an acetyl cholinesterase inhibitor was first isolated from species of Ircinia [316] and then later from a Coscinoderma species from Fiji and Palau when the structure was revised [317]. 

A Californian sponge of the Halichondriidae family contained a sulfated sesterterpene hydroquinone and five sulfated sesterterpenes. The structures of the halisulfates 1-5 (359-363) were determined by interpretation of spectral data and a structure was proposed for halisulfate 6 (364). The halisulfates are antimicrobial and antiinflammatory [318]. The absolute configuration of halisulfate 3 (361), which was also isolated from Ircinia sp. from the Philippines, has been determined by application of the chiral amide method and by chemical degradation techniques [319]. Halisulfate 7 (365) is a sesterterpene sulfate from a Coscinoderma sp. from Yap, Micronesia [320]. 

Bioassay directed isolation of serine protease inhibitors from Coscinoderma mathewsi yielded the 1-methylherbipoline salts (366-367) of known sesterterpenes halisulfate-1 (359) and suvanine (358) [321]. Coscinosulfate 1 (368), a sesquiterpene sulfate, was isolated from a New Caledonian collection of C. mathewsi. It displayed significant activity as an inhibitor of the protein phosphatase Cdc25 [322]. A total synthesis starting from (+)-sclareolide was described [323]. 

It demonstrated in vitro antimicrobial, antifungal and anti-HIV activities [24,133], Recently, a halisulphate derivative with antithrombin and antitrypsin activity was isolated from the marine sponge Coscinoderma mathewsi [134], The absolute configuration of halisulphate has been determined by application of the chiral amide method coupled with chemical degradation procedures [135],... 

Bokesch HR, Pannell LK, McKee TC, Boyd MR (2000) Coscinamides A, B and C, Three New Bis Indole Alkaloids from the Marine Sponge Coscinoderma sp. Tetrahedron Lett 41 ... 

Schmitz and co-workers next published a pair of papers that dealt with the isolation and characterization of sesterterpenes from two different sponges. The first of these reports described the structural characterization of phyllofolactones C and D, minor homoscalarane sesterterpenes from the Chinese sponge Phyllospongia foliascens.117 The structure of phyllofolactone-C (54) is shown. The second report detailed the characterization of halisulfate-7 (55), a sesterterpene sulfate from a sponge, Coscinoderma sp.118... 

Coscinoderma, Hyatteiia, Lendenfeldia, 10 Terpenes, macrolides, indolic derivatives... 

Loukad, A., Le Saout, I., Samadi, M., Lederc, S., Damiens, E., Meijer, L., Debitus, C., and Guyot, M. (2001) Cosdnosulfate, a CD25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. Bioorg. Med. Chem., 9, 3049-3054. 

Alea, G.V, Carroll, A.R., and Bowdert, B.F. (1994) Cosdrtoquinol, a new cytotoxic sesterterpene from a Dictyoceratid sponge, Coscinoderma sp. Aust. J. Chem., 47,191-194. 

De Marino, S., Festa, C., D Auria, M.V., Bourguet-Kondracki, M.-L., Petek, S., Debitus, C., Andres, R.M., Terendo, M.C., Paya, M., and Zampella, A. (2009) Coscinolactams A and B new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma matheivsi exerting anti-inflammatory properties. Tetrahedron, 65, 2905-2909. 

Halisulfate 7, a new sesterterpene sulfate from a sponge Coscinoderma sp. J. Nat. Prod., 62, 1190-1191. 

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