Coscinoderma mathewsi

Bioassay directed isolation of serine protease inhibitors from Coscinoderma mathewsi yielded the 1-methylherbipoline salts (366-367) of known sesterterpenes halisulfate-1 (359) and suvanine (358) [321]. Coscinosulfate 1 (368), a sesquiterpene sulfate, was isolated from a New Caledonian collection of C. mathewsi. It displayed significant activity as an inhibitor of the protein phosphatase Cdc25 [322]. A total synthesis starting from (+)-sclareolide was described [323]. 

It demonstrated in vitro antimicrobial, antifungal and anti-HIV activities [24,133], Recently, a halisulphate derivative with antithrombin and antitrypsin activity was isolated from the marine sponge Coscinoderma mathewsi [134], The absolute configuration of halisulphate has been determined by application of the chiral amide method coupled with chemical degradation procedures [135],... 

Loukad, A., Le Saout, I., Samadi, M., Lederc, S., Damiens, E., Meijer, L., Debitus, C., and Guyot, M. (2001) Cosdnosulfate, a CD25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. Bioorg. Med. Chem., 9, 3049-3054. 

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