Halichondriidae family

A Californian sponge of the Halichondriidae family contained a sulfated sesterterpene hydroquinone and five sulfated sesterterpenes. The structures of the halisulfates 1-5 (359-363) were determined by interpretation of spectral data and a structure was proposed for halisulfate 6 (364). The halisulfates are antimicrobial and antiinflammatory [318]. The absolute configuration of halisulfate 3 (361), which was also isolated from Ircinia sp. from the Philippines, has been determined by application of the chiral amide method and by chemical degradation techniques [319]. Halisulfate 7 (365) is a sesterterpene sulfate from a Coscinoderma sp. from Yap, Micronesia [320]. 

The structure of sokotrasterol sulfate (548), isolated from sponges of the family Halichondriidae was determined by X-ray analysis [453-455]. The steroid, 26-norsokotrasterol sulfate (549), was isolated from the marine sponge Trachyopsis halichondrioides and was identified by NMR spectroscopic analysis [456]. 

Tsujii, S., Rinehart, K. L., Gunasekera, S., Kashman, Y, Cross, S., Lui, M., Pomponi, S., and Diaz, M. C. (1988) Topsentin, bromotopsentin, dihydro-deoxybromotopsentin antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies. / Org. Ghent. 53,5446-5453. 

Makarieva, T.N., L.K. Shubina, A.I. Kalinovsky, V.A. Stonik, and G.B. Elyakov Steroids in Porifera. II. Steroid Derivatives from two Sponges of the Family Halichondriidae. Sokotrasterol sulfate, a Marine Steroid with a New Pattern of Side Chain Alkylation. Steroids 42, 267 (1983). 

In the classification of Bergquist (1978), order Halichondrida comprises the two families Halichondriidae and Hymenia-cidonidae, in that of Hooper (2000) it has four - Axinellidae, Desmoxyidae, DictyoneHidae and Halichondriidae - and in Systema Porifera, it has five - the four present in Hooper s scheme and the newfamily Bubariidae. As we have already... 

The study of the secondary metabolites of Halichondrida mainly concerns the families Axinellidae and Halichondriidae, which accormt for more than 90% of publications (850 out of 890) and isolated structures (860 out of 920). Within these two families, a few genera have been and continue to be studied, such as Axinella, Acanthella, PhakeUia and Ptilocaulis in the Axinellidae and Halichon-dria, Hymeniacidon, Axinyssa and Topsentia in the Halichondriidae. 

The sesterterpenes are also present among Halichondriidae, and an unidentified Californian species of this family yielded a series of sulfated derivatives generally... 

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