Corticotropin adrenocorticotropin, ACTH

Adrenocorticotropin (ACTH) Corticotropin-releasing hormone (CRH)(+) Adrenal cortex Glucocorticoids, mineralocorticoids, androgens... 

Meeran K (1989) Venepuncture causes rapid rise in plasma ACTH. Br J din Pract 1993 47 246-7 Raff H (1989) A new immunoradiometric assay for corticotropin evaluated in normal subjects and patients with Cushing s syndrome, din Chem 35 596-600 Raff H (1995) Intraoperative measurement of adrenocorticotropin (ACTH) during removal of ACTH-secreting bronchial carcinoid tumors. J Clin Endocrinol Metab 80 1036-9... 

Corticotropin, adrenocorticotropin, adreno-corticotrophic hormone, ACTH, SYSME HFRWG KPVGKKRRPV KVYPNGAE DE SAEAFPLEF, a 39-peptide hormone formed as a proteolytic cleavage product of proopiomelanocortin (POMC) in the adenohypophysis. The N-terminal sequence... 

ACTH, adrenocorticotropin hormone CRF, corticotropin-releasing factor (SF, cerebrospinal fluid HPA, hypothalamic—pituitary-adrenal. 

Intravenous bolus doses of 1 mg/kg produce transient facial flushing and, rarely, dyspnea. Adrenocorticotropin (Corticotropin, ACTH, ACTH, 24)... 

Corticotropin (ACTH) receptors have been used as the test preparations for comparison of the binding affinities of adrenocorticotropin peptides using a cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line (Kapas et al. 1996). Such assays measure the initial membrane binding but not strictly the biological activation e.g. of adrenal cells or melanocytes. 

Corticotropin is a peptide hormone secreted by the adenohypophysis, one of the derivatives of pro-opiomelanocortin (POMC) it acts primarily on the adrenal cortex, stimulating its grovrth and the secretion of corticosteroids. Its production is increased during times of stress. It is also known as adrenocorticotropic hormone, ACTH, corticotrophin, adrenocorticotrophin, and adrenocorticotropin. 

The adrenal gland produces cortisol in response to intermediate hormones, called adrenocorticotropin hormone (ACTH) and corticotropin-releasing hormone (CRH) via the humoral stress pathway, which extends from the brain to the adrenals (Figure 50-2). Once the body has received an environmental stress signal, it is detected by neurons in the cerebral cortex and transmitted to the hypothalamus. The hypothalamus then releases CRH via the classic secretory pathway into the anterior pituitary. CRH stimulates release of... 

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