Dexamethasone Corticosteroids

Augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid dexamethasone and inhibits both the acute and delayed phases of cisplatin-induced emesis... 

CORTICOSTEROIDS Dexamethasone Dexamethasone Cattle, pig, horse Muscle 0.5 0-0.015 Temporary MRLs ... 

Corticosteroids (dexamethasone, methylprednisolone) have antiemetic properties, but the basis for these effects is unknown. These agents are commonly used in combination with other agents in the... 

Melgert et al. studied the delivery of the corticosteroid dexamethasone to fibrotic livers [240], Dexamethasone has more potent and broader anti-inflammatory effects compared with naproxen. It inhibits the release of inflammatory mediators like TNF-a, IFN-y, and IL-6 and acts as an NFkB inhibitor [241, 242], Dexamethasone coupled to albumin (Dexa-HSA) was specifically taken up by sinusoidal cells in fibrotic rat livers, whereas dexamethasone itself was mainly taken up by hepatocytes. In vivo, Dexa-HSA promoted survival in endotoxin-induced liver inflammation in rats [240], In vitro, anti-inflammatory effects of the conjugate were measured in endotoxin-challenged liver slices. Dexa-HSA inhibited the release of nitric oxide and TNF-a in a dose-dependent manner (Melgert et al. unpublished data). To further enhance the delivery to KC at present dexamethasone is coupled to manHSA, and this conjugate is studied with respect to the pharmacokinetic profile and pharmacotherapeutic effects in fibrotic rats. 

Corticosteroids Dexamethasone and methylprednisolone used alone are effective against mildly to moderately emetogenic chemotherapy. Their antiemetic mechanism is not known, but may involve blockade of prostaglandins. These drugs can cause insomnia and hyperglycemia in patients with diabetes mellitus. 

ALMOTRIPTAN, ELETRIPTAN IMMUNOMODULATING DRUGS - CORTICOSTEROIDS-DEXAMETHASONE Possible 1 plasma concentrations of almotriptan and risk of inadequate therapeutic efficacy One of the major metabolizing enzymes of almotriptan - CYP3A4 isoenzymes - are induced by rifampicin. As there are alternative metabolic pathways, the effect may not be significant and can vary from individual to individual Be aware of possibility of 1 response to triptan, and consider t dose if considered to be due to interaction... 

Aim C C, Sullivan J J, First N L 1975 The effect of a corticosteroid (dexamethasone), progesterone, oestrogen and prostagiandin F2 on gestation iength in normal and ovariectomized mares. Journal of Reproduction and Fertility Supplements 23 637-640 Amann R P 1993 Effects of drugs or toxins on... 

Androgens Fluoxymesterone Testosterone Androgen antagonists Bicalutamide Flutamide Ketoconazole Nilutamide Aromatase inhibitors Aminoglutethimide Anastrazole Exemestane Letrozole Corticosteroids Dexamethasone Prednisone Estrogens Diethylstilbesterol Estradiol... 

Corticosteroids Dexamethasone-(Decadron) for CINV 10 mg prior to chemotherapy, repeat with IV Rx... 

Another major breakthrough in lead design is the steroid-eluting electrode (Figure 11.12). About 1 mg of a corticosteroid (dexamethasone sodium phosphate) is contained in a silicone core that is surrounded by the electrode material. The leaking of the steroid into the myocardium occurs slowly over several years and reduces the inflammation that results from the lead placement. It also retards the growth of the fibrous sack that forms around the electrode, which separates it from viable myocardium. As a result, the dramatic rise in acute thresholds that is seen with nonsteroid leads during the 8-16 weeks postimplant is nearly ehminated. 

Three corticosteroids (dexamethasone, flumethasone, triamcinolone acetonide) were recovered from feedstock and separated on a C g column (A = 242 nm) using a 50/50 methanol/water mobile phase [530], Baseline separation was achieved and elution was complete in 14 min. Detection limits of lOOpg/mL were reported. 

The corticosteroid dexamethasone has a poor aqueous solubility of 89 microgram/mL. It is given by the oral route for different diseases. When the medicine is given with a glass of water the oral route offers a dissolution volume of about 500 mL in the stomach. When the 4 mg dose used in rheumatic diseases is given by the oral route the dose number will be 0.09 and no major dissolution problems are to be expected. However, when dexamethasone is used in pyodermia gangrenosum the dose has to be 300 mg. At this dose, the dose number will be 6.7. This is close to 10 and the dissolution behaviour of the medicinal product has to be investigated in order to prevent incomplete absorption of the dexamethasone. 

Airway obstruction in the case of neck lesions, and compartment syndrome in extremities lesions should be carefully observed and managed accordingly (tracheostomy, fasciotomy). Systemic corticosteroid (dexamethasone 0.1 mg/kg intravenously every 8 h), and ice packs can be helpful to minimize the swelling. Gross hemoglobinuria can occasionally occur and is managed by hydratation and urine alkalization (95% dextrose and water mixed with 75 mEq/L of sodium bicarbonate), administered at twice the maintenance rate. Urine is monitored visually and usually clears within 6 h. 

The current US approach is to try to prevent the ATRA syndrome by high dose intravenous corticosteroids (Dexamethasone, 10 mg IV twice daily for three or more days) as soon as the first symptoms occur. This attitude proved very effective in the New York study, both for preventing the ATRA syndrome and reducing its mortality, from three in nine patients in the initial report to no fatalituies in the last two years [33, 40, 50]. It also proved efficient in a large US intergroup study [53]. However, as seen above, a recent European trial favours early introduction of chemotherapy in combination with ATRA, as it may reduce relapses. 

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