Dose numbers

Labeling. Labeling, controUed by FDA regulations, includes not only the affixed labels, but also the package inserts that provide mote detailed information. Trade, generic, or common name, dose, number of dose units present, and name and address of manufacturer and distributor ate requited. For nonptescription products, adequate directions for use ate requited. Prescription products must beat the phrase, "Caution Federal law prohibits use without a prescription" on theit labels. 

Explains the reason for the drug and prescribed therapy, including drug name, correct dose (number of sprays), and frequency of administration. 

Equations (25) and (26) show that the dissolution number will also influence the drug absorption in addition to the absorption and dose numbers. Assuming that the initial amount of drug in solution is insignificant compared to the amount of solid drug, the fraction of dose absorbed can be estimated by... 

Toxicity Classification Based on LD5o Fixed-dose Number of Laboratories Classifying Chemical ... 

Further predictions of in vivo drug absorption could be obtained by using fundamental dimensionless groups such as Do (dose number), Dn (dissolution number), and An (absorption number). The three dimensionless numbers are combinations of physiochemical and physiological parameters and represent the most fundamental view of GIT drug absorption and are the foundation principles of the BCS [3], Do is calculated using Eq. 2.26 ... 

An = absorption number = Do = dose number = Dn = dissolution number =... 

Level Gemcitabine dose Carboplatin dose Number... 

At higher temperatures and initial doses of TMS the reaction proceeds with a steady increase in pressure over 1000 min (Figure 2). However, at high dose number (> 5) the isotherms resemble those for reaction at lower temperatures. For doses 1-4 at 550°, and 1-3 at 450°, increase in pressure (Ap) vs. time plots obey the Elovich equation for activated adsorption ... 

Table4.1 Solutions to Eq. (15). Cs is drug solubility. C0 and Cf are the concentration at the beginning and at the end of the intestinal segment respectively. An - Absorption number, Do - dose number. See text for explanation.

Organization Continuation treatment (months at same dose) Number of episodes for long-term maintenance treatment... 

Number of adverse effects Rate per dose Number of adverse effects Rate per dose... 

Finally, the dose number (D0) is the ratio of dose to dissolved drug ... 

Figure 3.2 Graph of estimated fraction dose absorbed (F) vs dissolution number (Dn) and dose number (Do) for a high permeability drug [6], The dose number and the dissolution number ofdigoxin and griseofulvin are marked in the figure.

Figure 3.2. It can be seen that for high An, the critical range of the dose number and the dissolution number is around 1, where sharp changes in the fraction of drug absorbed are obtained due to small changes in D0 and Dn [6].

Digoxin and griseofulvin have about the same solubility ( 20 pg/ml), but a very different dose (0.5 and 500 mg, respectively). Consequently, while digoxin has a very low dose number (0.08), griseofulvin has a dose number, D0, of 133, which indicates that over 331 of water is required to dissolve a single griseofulvin dose. 

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