Corrected Mitotic Index

The MW index is evaluated as the number of mitoses per 10 hpf (high power field) and is calculated according to the following formula proposed by Haapasalo et al. (1989). 

Where n=number of microscopic fields studied (usually 10) 

Vv=volume fraction of neoplastic tissue (%) as expressed in the area fraction of neoplastic tissue in the microscope field this is estimated subjectively in the same field in which the mitotic count is made. 

MI=number of mitotic figures in a microscopic field from the area of highest neoplastic cellularity (during the measurement, the microscope is focused only once). 

FIGURE 5.3. The Gleason Grading System for prostatic carcinoma. 

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Lipponen, P. K., Kosma, V. M., Collan, Y., Kulju, T., Kosunen, O., and Eskelinen, M. 1990. Potential of nuclear morphometry and volume corrected mitotic index in grading transitional cell carcinoma of the urinary bladder. Eur. Urol. 77 333-337. 

Miliaras, D. 1999. Volume-corrected mitotic index and p53 immunoreactivity in borderline and malignant epithelial ovarian tumors. Anal. Quant. Cytol. Histol. 27 425M29. 

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