Coronin family

Edited by Barbara A. Burleigh and Dominique Soldati-Favre Volume 48 The Coronin Family of Proteins... 

The Coronin Family of Proteins, edited by Christoph S. Clemen, Ludwig Eichinger and Vasily Rybakin. 2008 Landes Bioscience and Springer ScienceH-Business Media. 

The seven-bladed propeller structure of the coronin family contains only five clearly identifiable WD repeats. These WD repeats are found between positions 79 and 305 in the murine coronin 1 (coronin lA). The first and last blades, 37-71 and 306-352 are either very highly modified WD repeats or were derived from a different source. While it is possible that five WD repeats were inserted into some pre-existing beta domain, this seems a bit unlikely given the standard Velcro-type propeller closure is employed. In addition the strand order in these two non WD repeats is the same as that in the five WD repeats. It is clear that the sequences of these two non WD repeats are by themselves diagnostic of the coronin family. 

One recurring question about the coronin family is how conserved are the interactions of coronins with actin Even though our knowledge of the family is far from comprehensive, I think that it is fair to say that interacting with actin is ancestral to the family and that actin-regulatory functions are likely to have evolved early and been retained by many members of the family. 

The coronin family shows its greatest diversity in mammals, in which it can be divided into three types. Type I includes coronins lA, IB and 1C [and coronin 6 for latest knowledge on coronin phylogeny sec chapter II-2], which like Crn Ip from yeast, have been shown to be involved... 

Oku T, Itoh S, Okano M et al. Two regions responsible for the actin binding of p57, a mammalian coronin family actin-binding protein. Biol Pharm Bull 2003 26 409-416. 

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