Coronary Artery Disease oxidative stress

Vassalle C, Botto N, Andreassi MG, Berti S, Biagini A (2003) Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease. Coron Artery Dis 14 213-218... 

Widlansky, M.E., Duffy, S.J., Hamburg, N.M., Gokce, N., Warden, B.A., Wiseman, S., Keaney, J.F., Jr., Frei, B., and Vita, J.A., Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radical Biol Med, 38, 499, 2005. 

Jonasson T, et al. Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease-a prospective randomized study of vitamin supplementation, Clin Chem Lab Med 2005 43(6) 628-634. 

If the patient with coronary artery disease also develops cardiac dysfunction, the same medications would be expected to apply, but for additional reasons. The re-instation of preconditioning mechanisms by ACEI administration has already been described. (I-blockers have additional mechanisms, such as an antiapoptotic and antioxidant action.276 In this situation oxidative stress is also predominant and may further exacerbate apoptotic mechanisms.277 The only drugs predictably diminishing oxidative stress in clinical usage are carvedilol and statins. The latter drug family is also used in heart failure. Exercise is also a standard preventive and therapeutic intervention in both the above categories. 

Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., and Mtinzel, T. (2001) Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease, Circulation 104, 2673-2678. 

CVDs are associated with higher amounts of cholesterol in the blood. The major causes of heart diseases include stress, high intake of refined sugars or oils, and constant consumption of animal fats [89]. In coronary disease, initially atherosclerotic plaques originate in the arteries, which become narrower towards the lumen, resulting in a decrease in blood flow. Initially, low density lipoproteins (LDL) deposit at scratched sites in the arteries and become oxidized after the depletion of protective substances (tocopherols). With the oxidation of LDL, the lipoproteins are oxidized and stimulate inflammatory reactions. Consequently, this... 

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