Core-shell mesoporous silica spheres

Zhu Y, Shah NH et al (2002) Influence of thermal processing on the properties of chlorpheniramine maleate tablets containing an acrylic polymer. Phaim Dev Technol 7(4) 481-489 ZhuY, Shi J et al (2005) Stimuli-responsive controlled dmg release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure. Angew Chem Int Ed 44 5083-5087 Zhu Y, Shah NH et al (2006) Controlled release of a poorly water-soluble drug from hot-melt extrudates containing acrylic polymers. Drug Dev Ind Pharm 32 569-583... 

Fig. 18 TEM images (a, b) of hollow mesoporous silica sphere (HMS) with a 3D pore network, core-shell structure, (c) with polyelectrolyte multilayer coating as a stimuli-responsive...

Y.F. Zhu, J.L. Shi, W.H. Shen, X.P. Dong, J.W. Feng, M.L. Ruan, and Y.S. Li, Stimuli-Responsive Controlled Drug Release from a Hollow Mesoporous Silica Sphere/Polyeleclrolyte Multilayer Core-Shell Structure, Angew. Chem. Ini. Ed., 44, 5083-5087(2005). 

J., Ruan, M., and Li, Y. (2005) Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/ polyelectrolyte multilayer core-shell structure. Angew. Chem., Int. Ed., 44, 5083-5087. 

The sphere synthesis has been extended into other materials. For example, mesoporous carbon capsules[285] with hollow core and mesoporous shell structures were synthesized using submicrometer-sized solid core and mesoporous-shell silica spheres as templates. 

Among metal oxide compositions, the chemistry of silica is the most widely studied and weU established, from the classical Stober synthesis of a silica sphere [23] to the recently developed surfactant-mediated synthesis of mesoporous silica [24, 25]. These developments were mainly enabled by the availability of stable silica precursors, their controllable hydrolysis and condensation, and the stable oxidation state of silica. Based on previously established chemistries, sol-gel or microemulsion methods were used to synthesize silica-shell-based core-shell NPs. 

W.R.Zhao, J.L. Gu, L.X. Zhang, H.R. Chen and J.L. Shi, Fabrication of Uniform Magnetic Nanocomposite Spheres with a Magnetic Core/Mesoporous Silica Shell Structure, / Am. Chem. Soc., 127, 8916-8917(2005). 

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