Hyaluronan core protein

Stem et aL [149] made use of a hyaluronan-binding protein obtained from the tryptic digestion of the proteoglycan core protein of bovine nasal cartilage to detect hy alumni da sc activities in urine samples from wiles tumor patients. The pathophysiology of this tumor is associated with major alterations in the metabolism of hyaluiouan, and it is thought that urinary hyaluronidase can be used as an additional marker. 

Spicer AP, Joo A, Bowling RA, Jr. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chrondroitin sulfate proteoglycan core protein genes. The missing links. J Biol Chem 2003 278 21083-21091. 

Figure 2.13 Participation of hyaluronan in formation of supramolecular complexes of proteoglycan aggregate. C 7, C2 and C3 are globular folded regions of the central core protein [41 ]. Reproduced from [4 7]. International Labor Office, Geneva...

Underhill C.B. (1989) The interaction of hyaluronate with the cell surface the hyaluronate receptor and the core protein, in Ciba Foundation Symposium 143 - The Biology of Hyaluronan (eds D. Evered, J. Whelan), John Wiley Sons, Ltd, Chichester, pp. 60-86. 

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