Core engineering requirements

The requiiements for scientific software development have continually increased. Besides the algorithmic core functionality, nowadays there is often a demand for a graphical user interface. In addition to the increasing importance of this visible component, which may still be seen as just an add-on, the software development itself has to fulfill stronger demands on software engineering requirements, such as maintainability and recoverability. 

Application to protein engineering requires the interaction of secondary structures to form tertiary sttuctures. DeGrado and coworkers recently accomplished de novo design of helical bundles composed of natural a-peptides [70]. In earlier work, they described three principles that guide the design process (1) complementary packing within the hydrophobic core, (2) specific interfacial interactions to promote... 

For many engineering purposes, a solid, and as near as possible continuous rock core, is required for examination. The core is cut with a bit and housed in a core barrel (Fig. 7.10). The bit is set with diamonds or tungsten carbide inserts. In set bits, diamonds are set on the face of the matrix. The coarser surface set diamond and tungsten carbide tipped bits are used in softer formations. These bits generally are used with air rather than with water flush. Impregnated bits possess a matrix impregnated with diamond dust, and their grinding action... 

The use of the computer in the design of chemical processes requires a framework for depiction and computation completely different from that of traditional CAD/CAM appHcations. Eor this reason, most practitioners use computer-aided process design to designate those approaches that are used to model the performance of individual unit operations, to compute heat and material balances, and to perform thermodynamic and transport analyses. Typical process simulators have, at their core, techniques for the management of massive arrays of data, computational engines to solve sparse matrices, and unit-operation-specific computational subroutines. 

Applications such as the noise attenuation panels that line engine inlets and exhausts require a special form of high temperature adhesive known as a reticulating adhesive. These bond honeycomb sandwich assemblies have inner facesheets with numerous small holes (Fig. 13). The holes and underlying honeycomb core... 

Chemical engineering undergraduate eurricula have traditionally been designed to train students for employment in the conventional chemical processing industries. The eurrent core emrieulum is remarkably successful in this effort. Chemical engineers will continue to play a major role in the ehemical and petroleum industries, but new areas of application as well as new emphases on environmental protection process safety and advanced computation, design, and proeess control will require some modifications of the curriculiun. 

Within a fuzzy system, an inference engine works with fuzzy rules it takes input, part of which may be fuzzy, and generates output, some or all of which may be fuzzy. Although the role of a fuzzy system is to deal with uncertain data, the input is itself not necessarily fuzzy. For example, the data fed into the system might consist of the pH of a solution or the molecular weight of a compound, both of which can be specified with minimal uncertainty. In addition, the output that the system is required to produce is of more value if it is provided in a form that is crisp "Set the thermostat to 78°C" is more helpful to a scientist than "raise the temperature of the oven." Consequently, the fuzzy core of the inference engine is bracketed by one step that can turn crisp data into fuzzy data, and another that does the reverse. 

Variations in ferritin protein coats coincide with variations in iron metabolism and gene expression, suggesting an Interdependence. Iron core formation from protein coats requires Fe(Il), at least experimentally, which follows a complex path of oxidation and hydrolytic polymerization the roles of the protein and the electron acceptor are only partly understood. It is known that mononuclear and small polynuclear Fe clusters bind to the protein early in core formation. However, variability in the stoichiometry of Fe/oxidant and the apparent sequestration and stabilization of Fe(II) in the protein for long periods of time indicate a complex microenvironment maintained by the protein coats. Full understanding of the relation of the protein to core formation, particularly at intermediate stages, requires a systematic analysis using defined or engineered protein coats. 

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