Copolymers glycol side chains

The influence of the structure of the main chain on the chymotrypsin catalyzed release of p-nitroaniline is shown in Fig. 15. Oligopeptide p-nitroanili-des were attached to HPMA copolymers (as side-chains) and to polyethylene glycol (end-point attachment). From the values of kcat/KM it is evident that all oligopeptide p-nitroanilides attached to PEG were cleaved faster than those attached to HPMA copolymers. It appeared that the PEG substrates fit better into the active site of chymotrypsin due to the linearity and flexibility of the PEG molecule, and the type of spacer attachments [255]. 

KD-6 copolymer of methyl methacrylate backbone with polyethylene glycol side chains... 

Fig. 4 Molecular structure of diblock copolymers and side-chain modified lipopolymers whose pressure-area isotherms are presented in Figs. 6 and 7, respectively. Diblock copolymers are poly(2-n-nonyl)-poly(2-methyl or 2-ethyl-2-oxazoline) (NxEy and NxMj,), where x and y denote the block sizes of the hydrophobic nonyl and hydrophilic oxazoline blocks. Side-chain modified lipopolymers, which contain short oligo-EG sidechains in each monomer of the lipopolymer to create a bottle-brush-like structure, are di-octadecanoyl-glycerol 2-(3 -methoxymonoethylene glycol)propyl-2-oxazoline (DiCigMEGOxn) and di-octadecanoyl-glycerol 2-(3 -methoxytiiethyleneglycol)propyl-2-oxazoline (DiCisTEGOxn) (adapted from [7,8])...

Polynaphthalenecarboxamide poly 17c bearing a chiral tri(ethylene glycol) side chain as an V-substituent also adopts a helical conformation. In contrast to V-substituted poly(p-benzamide), the folding of polylTc was enhanced by a solvophobic effect and seemed to be completed at 0-15°C in 70% water/methanol (7/3 v/v) [93]. The hydrophobicity of the naphthalene ring of poly 17 is enough to cause intramolecular self-association of the main chain in aqueous solvents. Furthermore, random copolymers of poly(naphthalenecarboxamide) 34 with chiral... 

Another important observation was the changed solubility properties of the modified copolymers, especially when a hydrophilic (entry 3) or a hydrophobic (entry 4) amine/acrylate pair was used. Furfurylamine (entry 10), 3-morpholinopropylamine (entry 11), and W,W-dimethylethylenediamine (entries 8, 12, 13) were tested as functional amines, giving pNlPAAm a multiresponsive character or providing the opportunity for further functionalization. 1-Ethoxyethyl acrylate (entry 8) was tested as a protected carboxylic acid derivative [148, 149] and 2-(2-ethoxyethoxy)ethyl acrylate (entries 7 and 13) introduced short ethylene glycol side chains to the polymer [52]. 

Solubilization of a graft copolymer comprising a hydrophobic poly(dodecyl-methacrylate) backbone and hydrophilic poly(ethylene glycol) monomethyl ether side chains in water/AOT/cyclohexane w/o microemulsions was rationalized in terms of the backbone dissolved in the continuous apolar phase and the side chains entrapped within the aqueous micellar cores [189],... 

He X, Zhang H, Yan D, Wang X. 2003. Synthesis of side chain liquid crystalline homopolymers and triblock copolymers with p methoxyazobenzene moieties and poly(ethylene glycol) as coil segments by atom transfer radical polymer zation and their thermotropic phase behavior. J Polym Sci Part A Polym Chem 41 2854 2864. 

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