Copolymerization with polyethylene glycol

Polyanhydrides because of their surface erosion properties can be ideal materials for a constant rate release profile (a zero order). Furthermore, these polyanhydrides are very hydrophobic and their hydrolytic degradation may take relatively a long time, which is not suitable for pulsatile release. Hence, in order to achieve a tunable erosion kinetics, a two-component polyanhydride made of SA precursor and CPP precursor when copolymerized with polyethylene glycol (PEG) was found to retain the surface erosion of two-component polyanhydride while increasing the erosion rate due to inaeased hydrophilicity by PEG functionality. Relatively faster erosion rates can be achieved by adjusting PEG precursor content [37]. 

The sole use for para-xylene is to make terephthalic acid (TPA) and its derivative, dimethyl terephthalate (DMT). When DMT is copolymerized with ethylene glycol, chemists call it polyethylene terephthalate. On Seventh Avenue in New York, they call it polyester. On the labels, it is sometimes called Dacron. 

Cross-linked supports have also been made by copolymerization of polyethylene glycol terminated with methacrylate groups with cross-linking agents such as trimethylolpropane trimethacrylate.166 This type of resin has also been used as phase-transfer catalysts.167... 

Microgels may also be produced by dispersion polymerization of multifunctional monomers [276, 277]. Kim et al. synthesized microgels by copolymerization of acrylamide with acryloyl terminated polyethylene glycol macro-monomers in ethanol or in selective solvents [276]. The macromonomer acted... 

Listed in Table 8 are the results of the polymerization and copolymerizations of VBFU. VBFU was quantitatively polymerized and/or copolymerized with maleic anhydride (MAn) or methacryloyl terminated polyethylene glycol) macronomer (PEG) to give a polymeric drug containing 5-FU. The latter afforded a... 

Vinyl polyethylene glycol ethers Non ionic Used in the copolymerization with acrylates to produce water-soluble polymers ... 

An elegant example of the analysis of colloid surfaces containing covalently attached hydrophilic species has been provided by Brindley et al who studied the surface chemistry of polystyrene colloids with surface grafted polyethylene glycol groups [39]. These colloids were prepared by surfactant-free copolymerization of styrene with PEG using potassium persulphate as an initiator. The XPS analysis of these microparticles is shown in Fig. 11. 

The copolymerization in miniemulsion was not limited to systems for which the monomers were in the dispersed phase. Rather, copolymerization could also be carried out with monomers of opposite polarity - that is, with one comonomer in each phase - in both direct and inverse miniemulsion [26]. Water-soluble, surface active, and oil-soluble initiators were employed to start the polymerizations, as shown in Figure 15.2. Oil-soluble initiators were found to produce a higher yield of copolymers of acrylamide and methyl methacrylate with a low degree of blockiness than did water-soluble or surface-active initiators. In contrast, the surface-active polyethylene glycol (PEG) azo-initiator yielded polymers that were almost free from homopolymers, and with a low degree of blockiness, when acrylamide and styrene were copolymerized. At the interface, monomers that only copolymerize alternately [27] as water-soluble poly(hydroxy vinyl ether)s were also successfully polymerized with oil-soluble maleate esters, to yield polymer nanocapsules. 

---