Convulsions in children

Reducing the availability of GABA by blocking the synthesising enzyme GAD also promotes convulsions. This may be achieved by substrate competition (e.g. 3-mercapto propionic acid), irreversible inhibition (e.g. allylglycine) or reducing the action or availability of its co-factor pyridoxal phosphate (e.g. various hydrazides such as semi-carbazide). In fact pyridoxal phosphate deficiency has been shown to be the cause of convulsions in children. 

The normal body temperature is 36.8°C. Babies under 6 months of age who have a higher temperature than 37.7°C should be referred on the same day. Babies over 6 months should be referred if their temperature is above 38.2°C. Babies who have had a temperature-related convulsion lasting 15 minutes or longer should receive pharmacotherapy in the form of either lorazepam, diazepam or clonazepam. Febrile convulsions in children usually cease spontaneously within 5-10 minutes and are rarely associated with significant sequelae and therefore long-term anticonvulsant prophylaxis is rarely indicated. Parents should be advised to seek professional advice when the child develops fever so as to prevent the occurrence of high body temperatures. 

Less common toxic effects of systemic use include excitation and convulsions in children, postural hypotension, and allergic responses. Drug allergy is relatively common after topical use of H4 antagonists. The effects of severe systemic overdosage of the older agents resemble... 

Momordica charantia can cause hypoglycemic coma and convulsions in children (316). 

It has been said that the medicine will ward off asthmatic and epileptic convulsions, but there would appear to be no reliable confirmation of this. The claim may have originated with Culpeper, who writes, concerning Heartsease "The spirit of it is excellently good for the convulsions in children, as also for falling sickness, and a gallant remedy for the inflammations of the lungs and breast, pleurisy, scabs, itch, etc."... 

When used in recommended dosages, antihistamines are reasonably safe dmgs. Acute toxicity after massive doses is characterized by marked CNS stimulation (convulsions) in children and depression (coma) followed by stimulation (convulsions) in adults. Coma, cardiorespiratory feilure, and death follow convrrlsions in cases of severe toxicity. 

Miura T, Kimura K. Theophylline-induced convulsions in children with epilepsy. Pediatrics 2000 105(4 Part 1) 920. 

Voacanga ajricana Liliaceae Antioxidant activity, cardiac spasms, caries, disinfectant, fatigue, amebic dysentery, asthma, diarrhea, edema, leprosy, convulsions in children, to calm the insane, epilepsy. 17, 31... 

In Cote d Ivore voacanga is traditionally used against leprosy, diarrhea, generalized edema, convulsions in children, madness, diuretic and infant tonic 1-3). Bark or root bark decoctions is drunk for cardiac spams, stomac, hernia and post partum pain, kidney troubles (5). 

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