Convulsion chlorpromazine

The role of chlorpromazine in facilitating metrizamide-induced convulsions has been confirmed in animal studies... 

The role of cardiac effects of neuroleptic drugs in sudden death is controversial (SEDA-18, 47 SEDA-20, 26 SEDA-20,36). There may be multiple non-cardiac causes, including asphyxia, convulsions, or hyperpyrexia. However, some cases of sudden death in apparently young healthy individuals may be directly attributable to cardiac dysrhythmias after treatment with thioridazine or chlorpromazine (10), and from time to time, cases of sudden death are reported (SEDA-20, 36 SEDA-22, 46), including four cases in which thioridazine in standard doses was implicated as the cause of death or as a contributing factor (11). 

Overdose is common amongst users (up to 22% of heavy users report losing consciousness). The desired euphoria and excitement turns to acute fear, with psychotic symptoms, convulsions, hypertension, haemorrhagic storke, tachycardia, arrhythmias, hyperthermia coronary vasospasm (sufficient to present as the acute coronary syndrome with chest pain and myocardial infarction) may occur, and acute left ventricular dysfunction. Treatment is chosen according to the clinical picture (and the known mode of action), from amongst, e.g. haloperidol (rather than chlorpromazine) for mental disturbance diazepam for convulsions a vasodilator, e.g. a calcium channel blocker, for hypertension glyceryl trinitrate for myocardial ischaemia (but not a p-... 

ANTICONVULSANTS are drugs used to treat convulsions of various types, for instance, in drug or chemical poisoning, e.g. chlorpromazine, diazepam. However, these anticonvulsants are not necessarily effective or suitable for epilepsy. 

Occasional Confusion amnesia disinhibition paradoxical excitement depression dizziness witiidrawal symptoms, including convulsions, on abrupt discontinuance (witiidrawal may be especially difficult with alprazolam) rebound insomnia or excitement Rare Hypotension blood dyscrasias jaundice allergic reactions paradoxical rage reactions stuttering with alprazolam BUPROPION, Anxiety agitation insomnia tremor anorexia BUSPIRONE, Dizziness headache nausea paresthesias diarrhea CHLORDIAZEPOXIDE, see Benzodiazepines CHLORPROMAZINE, see Phenothiazines, aliphatic CHLORPROTHIXENE, similar to Phenothiazines CLOMIPRAMINE, see Tricyclic antidepressants CLORAZEPATE, see Benzodiazepines CLOZAPINE... 

An isolated case of convulsions in a child was attributed to the use of piperazine followed by chlorpromazine. 

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