Neuronal calcium channels

These include nicotinic acetylcholine receptors, neuronal calcium channels, muscle sodium channels, vasopressin receptors, and iV-methyl-D-aspartate (NMDA) receptors. Some general features of the structure, function, and evolution of biologically active peptides isolated from Conus venom are presented. [Pg.256]

In the venom of C. geographus and other fish-hunting species, the conotoxins isolated so far can be divided into three major classes (1-4) o -conotoxms which block neuronal calcium channels at the presynaptic terminus of the neuromuscular junction, a-conotoxins which inhibit the acetylcholine receptor at the postsynaptic terminus, and x-conotoxins which block Na channels on the muscle membrane. [Pg.267]

Olivera BM, Cruz LJ, De Santos V, LeCheminant G Griffin D, Zeikus R, McIntosh JM, Galyean R, Varga J. (1987) Neuronal calcium channel... [Pg.148]

Miljanich GP. (2004) Ziconotide Neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem 11 3029-3040. [Pg.149]

Bourinet, E., Soong, T.W., Stea, A., Snutch, T.P. Determinants of G-protein-dependent opioid modulation of neuronal calcium channels, Proc. Natl. Acad. Sci. USA 1996, 93, 1486-1491. [Pg.374]

Miljanich, G.P. and Ramachandran, J. Antagonists of neuronal calcium channels structure, function and therapeutic implications, Ann. Rev. Pharmacol. Toxicol. 1995, 35, 707-734. [Pg.376]

Tsien, R.W., Lipscombe, D., Madison, D.V., Bley, K.R., Fox, A.P. Multiple types of neuronal calcium channels and their selective modulation, Trends Neurosci. 1988, 11, 431-438. [Pg.377]

Patil PG, Brody DL, Yue DT (1998) Preferential closed-state inactivation of neuronal calcium channels. Neuron 20 1027-1038. [Pg.249]

It has been known for a long time that the skeletal muscle L-type calcium channel complex also contains a y subunit - a four transmembrane helix with cytoplasmic bland C-termini (Arikkath and Campbell 2003). Seven additional potential candidates for neuronal calcium channel y subunits have been identified however, it is not clear if these are bona fide calcium channel subunits. Indeed, the first identified neuronal calcium channel y subunit stargazin has also been linked to AMPA receptor trafficking and pharmacology (Chen et al. 2000 Tomita et al. 2005). Hence, it remains unclear to what extent these subunits associate with the calcium channel complex in neurons. [Pg.51]

Stea A, Soong TW, Snutch TP (1995) Determinants of PKC-dependent modulation of a family of neuronal calcium channels. Neuron 15 929 10... [Pg.73]

Zamponi GW, Soong TW, Bourinet E, Snutch TP (1996) Beta subunit coexpression and the alphal subunit domain I-II linker affect piperidine block of neuronal calcium channels. J Neurosci 16 2430-43... [Pg.74]

Edwards DA, Kim J, Alger BE (2006) Multiple mechanisms of endocannabinoid response initiation in hippocampus. J. Neurophysiol. 95(l) 67-75 Elmslie KS (2003) Neurotransmitter modulation of neuronal calcium channels. J Bioenerg Bio-membr 35(6) 477-89... [Pg.469]

Elmslie KS (2003) Neurotransmitter modulation of neuronal calcium channels. J Bioenerg Bio-membr 35 477-89... [Pg.517]

Ducros A, Denier C, Joutel A et al (2001) The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. N Engl J Med 345 17-24 Evans RW, Linder SL (2002) Management of basilar migraine. Headache 42 383-384... [Pg.15]

Miljanich GP. Ziconotide neuronal calcium channel blocker for... [Pg.1476]

Indications Analgesic, severe chronic pain Category Neuronal calcium channel blocker Half-life 4.6 hours... [Pg.622]

Nowycky MC, Fox AP, Tsien RW. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 1985 316(6027) 440-3. [Pg.139]

Wright CE, Angus JA. Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission. BrJ Pharmacol 1996 119(l) 49-56. [Pg.144]

A. Takahara, S. Fujita, K. Moki, Y. Ono, H. Koganei, S. Iwayama, and H. Yamamoto. Neuronal calcium channel blocking action of an antihypertensive drug, Cilinidipine, in IMR-32 human neuroblastoma cells. Hypertension Research 26 743-747 (2003). [Pg.204]

R., Varga, J., Gray, W. R. and Rivier, J. 1987. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using co-conotoxins from Conus magus venom. Biochemistry 26 2086-2090. [Pg.166]

Olivera, B.M., 1987, Neuronal Calcium channel Antagonists. Discrimination between Calcium Channel Subtypes using co-Conotoxin from Conus magus Venom, In Biochemistry, 26, 2086-209. [Pg.462]

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