Polymers controlled release

Brem, H., Kader, A., Epstein, J. I., Tamargo, R., Domb, A., Danger, R., and Leong, K., Biocompatibility of bioerodible controlled release polymers in the rabbit brain. Selective Caacer Therapeutics. 5, 55-65, 1989. [Pg.70]

S. Luo and D. R. Walt, Fiber-optic sensors based on reagent delivery with controlled-release polymers. Anal. Chem, 61, 174-177 (1989). [Pg.220]

S. M. Barnard and D. R. Walt, Chemical sensors based on controlled-release polymer systems,... [Pg.495]

Hsieh, D., Rhine, W., and Langer, R. Zero-order controlled release polymer matrices for micro and macro-molecules. J. Pharm. Sci. 72 17-22, 1983. [Pg.134]

Optical Immunosensors Using Controlled Release Polymers... [Pg.312]

Fiber-optic sensors based on controlled-release polymers provide sustained release of indicating reagents over long periods. This technique allows irreversible chemistries to be used in the design of sensors for continuous measurements. The sensor reported in this paper is based on a fluorescence energy transfer immunoassay. The sensor was cycled through different concentrations of antigen continuously for 30 hours. [Pg.312]

Our approach of using controlled-release polymers to construct reservoirs of irreversible indicating chemistries allows sensors to be developed that operate continuously and for long periods. The approach has several advantages ... [Pg.322]

A commercial controlled release, polymer coated spheroid/bead product (Slophyllin, Rona) was used as received. The spheroids were microtomed to expose a cross-sectional area of the inner drugladen core and the surrounding polymer film coating, and subsequently mounted on the sample holder using conductive silver paint with the microtomed surface uppermost. [Pg.102]

Table 6.3 Some commonly used controlled-release polymers...

Zhu, W. Lockwood, G.B. Enhanced biotransformation of terpenes in plant cell suspensions using controlled release polymer. Biotechnol. Lett. 2000, 22, 659-662. [Pg.658]

Tierney TS, Clatterbuck RE, Lawson C, Thai Q-A, Rhines LD, Tamargo RJ. 2001. Prevention and reversal of experimental posthemorrhagic vasospasm by the peri-adventitial administration of nitric oxide from a controlled-release polymer. Neurosurgery 49 945-53... [Pg.606]

Brem, H. Kader, A. Epstein, J.I. Tamargo, R.J. Domb, A. Langer, R. Leong, K.W. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Selec. Cancer Ther. 1989, 5 (2), 55-65. [Pg.2256]

Keywords Proteins Controlled release Polymers Liposomes Microcrystals Pulmonary... [Pg.141]

Aizawa M 1991 Immunosensors Biosensor Principles and Applications ed L J Blum and P R Goulet (New York Dekker) pp 249-66 Barnard S M and Walt D R 1991 Ghemical sensors based on controlled release polymer systems Science 251 927-9... [Pg.128]

Fig. 6. Top view and x-ray of a controlled release polymer matrix containing magnetic beads and a drug.

Controlled-release polymer implants are useful for delivering drugs directly to the brain interstitium. This approach may improve the therapy of brain tumors or other neurologieal disorders. The mathematical models described in this section—which are based on methods of analysis developed in earlier chapters—provide a useful framework for analyzing mechanisms of drug distribution after delivery. These models describe the behavior of chemotherapy compounds very well and allow prediction of the effect of changing properties of the implant or the drug. More complex models are needed to describe the behavior of macromolecules, which encounter multiple modes of elimination and metabolism and are subject to the effects of fluid flow. [Pg.303]

Figure 2 (a) Bulk erosion of biodegradable controlled-release polymer implants leads to unpredictable release profiles, (b) Polymers exhibiting surface erosion release drug at nearly constant rate (zero-order kinetics) as they dissolve in water. (From Ref. 61.)... [Pg.330]

Tamargo RJ, Myseros JS, Epstein JI, Yang MB, Chasin M, Brem H. Interstitial chemotherapy of the 9L gliosarcoma controlled release polymers for drug delivery in the brain. Cancer Res 1993 53 329-333. [Pg.366]

Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, Brem H. Brain biocompatibility of a biodegradable, controlled-release polymer in rats. J Biomed Mater Res 1989 23 253—266. [Pg.370]

Sipos EP, Tyler B, Piantadosi S, Burger PC, Brem H. Optimizing interstitial delivery of BCNU from controlled release polymers for the treatment of brain tumors. Cancer Che-mother Pharmacol 1997 39 383-389. [Pg.372]

Processing at 100°C Degradation onset is >200°C Low Tg can limit stability Extrudable at moderate temperatures, >100°C Excellent CR polymer Extrudable at low temperatures, >60°C Excellent controlled release polymer but non-biodegradable... [Pg.1131]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...