Controlled drug delivery nanoparticles

F Jaeghere, E Doelker, R Gurny. Nanoparticles. In E Mathiowitz, ed. Encyclopdia of Controlled Drug Delivery, Vol. 2. New York John Wiley Sons, 1999, pp 641-664. 

RH Muller, K Mader, S Gohla. Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art. Eur J Pharm Biopharm 50(1) 161-177, 2000. 

Nanoparticles show great promise as devices for the controlled release of drugs, provided that the choice of material for nanoparticle formation is made with the appropriate considerations of the drug cargo, administration route, and the desired site of action. The use of nano- and microparticles as controlled drug-delivery devices has recently been extensively reviewed [97]. 

Muller, R.H., K. Mader, S. Gohla, Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery A Review of the State of the Art, European Journal of Pharmaceutics and Biopharmaceutics. 50, 161, 2000. 

Schwarz C. and Mehnert W., Solid lipid nanoparticles (SEN) for controlled drug delivery. 11. Drug incorporation and physicochemical characterization, J. Microencapsulation, 16, 205, 1999. 

This change was found to be reversible if the corona block is not too large and may become of interest for controlled drug delivery applications. It was also shown that these systems can host gold nanoparticles in the P2VP shell [93],... 

Couvreur, P., C. Dubernet, et al. (1995). Controlled drug delivery with nanoparticles Current possibilities and future trends. Eur. J. Pharm. Biopharm. 41 2-13. 

Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, Wei G, Hao JS, Cui FD (2002) Bioadhesive polysaccharide in protein delivery system chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249(1-2) 139-147 Park K, Robinson JR (1984) Bioadhesive polymers as platforms for oral-controlled drug delivery method to study bioadhesion. Int J Pharm 19 107-127 Patel H, Ryman BE (1981) Systemic and oral administration of liposomes. In Knight CG(ed) Liposomes From Physical Structure To Therapeutic Applications, Elsevier, Amsterdam, pp 409-441... 

Muller, R.H. Mehnert, W. Lucks, J.-S. Schwarz, C. Muhlen, A. Weyhers, H. Ereitas, C. Ruhl, D. Solid lipid nanoparticles (SLN)—an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. 1995, 41 ( ), 62-69. 

Brannon-Peppas, L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int. J. Pharm. 1995, 116, 1-9. 

Keywords Drug delivery systems Targeted drug delivery Nanoparticles Nanobiotechnology Personalized medicine Routes of drug administration Drug delivery devices Controlled release Protein/peptide delivery Drug formulations... 

Figure 1 Formulation of controlled drug delivery systems using the supercritical fluid-derived RESS process (A) films, (B) microparticles/nanoparticles/ liposomes, (C) coated products including microcapsules, and (D) microporous foams.

Micro- and nanoparticles are very fine particles with a small linear size. The size range of microsystems is 100-1000 pm, while nanoparticles fall within the lower range of the colloid dimension, their typical size is between 15-300 nm [5-7, 57, 58]. The pharmaceutical application of these important systems, the process of controlled drug delivery, is dealt with in several publications. Some of the major, comprehensive publications are cited [47-56]. 

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