Control screening, first-level

In terms of environmental metrics to assess processes, it is clear that a considerable testing burden exists to assess potential environmental hazards that lead to a credible risk assessment. As a first step, one would typically screen compounds from an environmental hazard perspective to assess their tendency for persistence, bioaccumulation, and toxicity. Depending on the final application of tlie compound, one might then avoid commercial production of a particular compound or devise processes that would use the compound but control the environmental risk to acceptable levels. For this, it is important to perform a process-specific risk assessment, as the impact of a given chemical, or set of chemicals, will be affected... 

All collaborators correctly identified naturally contaminated corn (101 ng/g) and raw peanut (69 ng/g) positive samples. No false positives were found for control samples containing <2 ng/g. Overall (excluding poultry feed) the average correct responses for spiked positive samples at 10, 20 and >30 ng/g levels were 52, 86 and 96%, respectively (see Figure 2). The method was rapid and simple and was adopted Official First Action by the AOAC as a screening procedure for aflatoxins at >20 ng/g in cottonseed and peanut butter, and >30 ng/g in corn and raw peanuts. (In this case the AOAC required a positive rate of 90% for acceptance.)... 

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