Contractile property

Bigland-Ritchie, B. Woods, J.J. (1984). Changes in muscle contractile properties and neural control during human muscular fatigue. Muscle Nerve 7. 691-699. 

Sacco, P., Jones, D.A., Dick, J.R.T. and Vrbova, G. (1992). Contractile properties and susceptibility to exercise-induced damage of normal and mdx mouse tibialis arterior muscle. Clin. Sci. 77, 757-760. 

Kotlikojf These animals have an altered contractile response to agonists in vitro. This is about as much as we can say at the moment. We do see a phenotype in terms of their contractile properties. In the RyR2 knockouts we would expect to have a loss of stretch-induced Ca2+ release and CICR in smooth muscle. If you have normal pressurized vasomotor responses in those animals, I think this would suggest that the phenomenon that we have described is not essential for myogenic tone. 

Mechanical Work. All cells exhibit motile and contractile properties. The remarkable thing about these activities of cells is that they are based on the direct coupling of chemical to mechanical action, in contrast to the heat engines that we have developed to perform our work for us. The mechanisms by which this coupling of chemical to mechanical processes takes place is not well understood, but the hydrolysis of adenosine triphosphate is known to be an important part of the molecular pathway. Although thermodynamic studies cannot provide information about the molecular steps involved, any mechanism that is proposed must be consistent with thermodynamic data [4]. 

This section will report on our studies of the contractile properties of several polymers and our work with a composite of gels with specific functions ... 

Rodgers CD, Paterson DH, Cunningham DA, Noble EG, Pettigrew FP, Myles WS, Taylor AW. Sleep deprivation effects on work capacity, self-paced walking, contractile properties and perceived exertion. Sleep 1995 18 30-38. 

Contractile properties in rodents can be measured either in vitro in a dissected muscle or in vivo in an intact preparation with an anesthetized animal (e.g., (19-20)). Measurements made under isometric conditions are perhaps most common and use the most straightforward setup. The addition of servomotors for dynamic control of muscle length allows simulation of dynamic conditions (eccentric, isotonic, etc.) that may be modified by disease or other processes (22, 23). For in vitro studies, the muscle is anchored by ligating the tendon (origin) to a support, for in vivo studies, the bone (femur) is clamped to prevent movement. The other tendon (insertion) is then coupled to a force transducer. In both cases, a recording electrode is also placed in contact with the muscle to record the compound action potential, and a stimulating electrode is used to stimulate the nerve or the muscle, as described below. 

Brooks, S. V. and Faulkner, J. A. (1988) Contractile properties of skeletal muscles from young, adult and aged mice. J Physiol 404, 71-82. 

A third phase of progressive decline of neurotransmission with strong decrease of e.p.p.s and m.e.p.p.s and no alteration of muscle contractile properties (reviewed in Harris 1997 Howard and Gundersen 1980 Montecucco and Rossetto 2000 Rowan 2001). 

Differences in electrophysiological and contractile properties of mammalian cardiac tissues bathed in bicarbonate- and HEPES-buffered solutions, Acto Physiol. Scand.YT, 11-18, 2003 Mash, H.E., Chin, Y.P., Sigg, L. et al., Complexation of copper by zwitterionic aminosulfonic (good) buffers. Anal. Chem. 75, 671-677, 2003 Sokolowska, M. and Bal, W., Cu(ll) complexation by non-coordinating M2-hydroxyethylpiperazine-iV -ethanesulfonic acid (HEPES buffer), J. Inorg. Biochem. 99, 1653-1660, 2005 Zhao, G. and Chasteen, N.D., Oxidation of Good s buffers by hydrogen peroxide, Anal. Biochem. 349, 262-261, 2006 Hartman, R.F. and Rose, S.D., Kinetics and mechanism of the addition of nucleophiles to alpha,beta-unsaturated thiol esters, J. Org. Chem. 71, 6342-6350, 2006. 

Pericytes surround brain capillaries and are integrated into the basal membrane. They exhibit contractile properties, have phagocytic activity, and release growth hormones that are necessary for the proper assembly of capillaries. 

Cell Type Structure Contractile Properties Function... 

G-actin is very highly conserved, both across actin genes within a species and across species. Apparently, the need for so many functional binding sites in a molecule of that size leaves few options for nonlethal mutations. Among the actins sequenced from 30 widely divergent species, there were only 32 amino acid substitutions. One implication of this is that when differences in contractile properties are observed between various types of muscle, those differences must be due to the motor protein (myosin) or to the various regulatory proteins. 

Dekhuijzen PNR, Gayan-Ramirez G, de Bock V, et al. Triamcinolone and prednisolone affect contractile properties and histopathology of rat diaphragm differently. J Clin Invest 1993 92 1534-1542. 

Because of the qualitative similarities of the mechanical properties in smooth and striated muscles, much research over the past several decades has focused on determining whether the functional behavior of these muscles can be explained on the basis of simUar mechanisms. However, the unique structural features of smooth muscle are likely to underly some aspects of its contractile properties which differ significantly from those of striated muscles. In addition, smooth muscle tissues possess a number of distinctive functional properties that are not easily accounted for on the basis of models developed to account for the properties of striated muscles. 

Parente JE, Walsh MP, Kerrick WG, Hoar PE (1992) Effects of the constitutively active proteolytic fragment of protein kinase C on the contractile properties of demem-branated smooth muscle fibres. J Muscle Res Cell Motil 13 90-99... 

Actomyosin threads made from actomyosin which has been repeatedly precipitated contain no other proteins, and the salt concentration depends only on the composition of the bath. Those contractile properties which are common both to the extracted muscle fiber (fiber model) and the actomyosin thread (thread model) can therefore be ascribed to the actomyosin. 

Some of the contractile properties of the models, however, differ markedly from those of the particular muscle from which they have been prepared (Table II, columns 1, 5 and 7). One of the most important of these differences, perhaps, is the slowness with which the models redevelop their tension after a release the time in the case of living muscle is short and characteristic of the speed of contraction (A. V. Hill, 1926 Gasser and Hill, 1924). It is hardly surprising that an actomyosin thread from a striated muscle no longer has the same short recovery time as that of the muscle (Table II, column 5), for the actomyosin from both slow and fast muscles appears to be much the same (Hamoir 1949). Actin and I.-myosin from quite different animals combine to give acto-myosins with the characteristic properties of the natural ones (Cigada... 

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