Contraceptive rings

Two synthetic estrogens are used in hormonal contraceptives in the United States, ethinyl estradiol (EE) and mestranol. Mestranol must be converted to EE in the liver to be active. It is approximately 50% less potent than EE. Most combined oral contraceptives (OCs) contain estrogen at doses of 20 to 50 meg of EE daily. The contraceptive ring produces one-half the serum concentration of EE derived from a 30-mcg OC. 

Brache V, Alvarez-Sanchez F, Faundes A, Jackanicz T, Mishell DR Jr, Lahteenmaki P. Progestin-only contraceptive rings. Steroids 2000 65(10-11) 687-91. 

Despite the head start afforded to progestogen-only vaginal rings, the first contraceptive ring to reach market was the combined contraceptive ring, NuvaRing. It is a nonbiodegradable,... 

Contraceptive rings Same as above for oral Same as above for oral Same as above for oral 1 ... 

Which statement indicates to the nurse that the client using a vaginal contraceptive ring understands the birth control teaching ... 

Vaginal Rings. Vaginal epithelium is readily permeable to contraceptive steroids. Since the vascular drainage of the vagina bypasses the Hver, this route of adrninistration potentially permits utilisation of dmgs that have low oral activity. 

Novel steroids which contain an isoxazole fused ring within the structure have biological activity which is primarily contraceptive (74MI41604, 79MI41607, 79USP4160027) and a variety of other indications (75USP3869467, 75ZOB2090). 

Non-oral forms of contraceptives, such as the transdermal patch and the transvaginal ring, avoid the need for daily administration and, as such, may enhance convenience of use for the patient. 

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