Continuous sample inlet, liquid chromatography

While the dual inlet technique is generally the most precise method for stable isotope ratio measurements, the continuous-flow technique offers online sample preparation, smaller sample size requirements, faster and simpler analyses, increased cost-effectiveness, and the possibility of interfacing with other preparation techniques, including elemental analysis, gas chromatography (GC), and liquid chromatography (LC). For these reasons, CF-IRMS is the subject of the majority of research currently being conducted in the field of forensic science [1],... 

Both FAB and LSIMS can be used in conjunction with continuous-flow inlet systems to optimise sensitivity, to improve reproducibility and to allow the use of in-line liquid chromatography for LC-MS. In the flow technique an LC pump delivers a continuous flow of solvent (containing a low concentration of the FAB/LSIMS matrix) to the point where the atom or ion beam is applied. The sample is introduced into this solvent flow by an LC injection valve and is delivered to the point of ionisation in a sharp concentrated slug. A good account of the method of continuous flow FAB is given in reference [5]. 

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