Contact symptoms

Health EBizards Information - Recommended Personal Protective Equipment Organic canister or air pack rubber gloves, goggles other protective equipment as required to prevent all body contact Symptoms Following Exposure Vapors are quite irritating to eyes, nose and throat. Eye irritation may... 

Acute ICD develops when the skin is exposed to a strong irritant or caustic chemical. Usually, this happens as an accident at work or in special emergency situations. The irritant reaction reaches its peak quickly, then starts to heal this is called the decrescendo phenomenon. Because the lag time is short (usually minutes to hours after exposure) and the association between exposure and skin symptoms is usually clear, the diagnosis is easy in most cases. It may become difficult when the patient was unaware of an exposure. Acute ACD has to be considered as differential diagnosis and is caused by a delayed sensitisation reaction 24-48 h after allergen contact, symptoms appear. This type of contact dermatitis is... 

Nonspecific disruption of membrane permeability was proposed for difenopenten-ethyl ethyl 4-[(4-trifluoromethyl)phenoxyl-2-pentanoate, which uncoupled and inhibited respiration in corn and soybean mitochondria. This was considered to be a secondary effect of this aryloxy-phenoxypropionate analogue (see Chapter 3) due to the relatively high in vitro concentration. A similar conclusion was made for another aryl-oxyphenoxypropionate, diclofop, which uncoupled state 4 respiration, inhibited state 3 respiration, and caused swelling of isolated wheat and wild oat mitochondria. The inhibition of respiration was proposed to be due to an effect prior to the electron transport chain, that is, an effect on succinate or malate dehydrogenase. A potent inhibition of state 3 respiration was also reported for the herbicide UK J72J (2-ethylamino-4-amino-5-thiomethyl-6-chloropyrimidine), with succinate as substrate.Difenzoquat also inhibits state 3 respiration in isolated wheat and wild oat mitochondria however, this was not thought to be a significant contribution to the chlorotic contact symptoms observed with this translocated herbicide. Difenzoquat also possesses a weak bipyridinium-type PSI electron acceptor activity which causes chlorosis. ... 

Nickel carbonyl is volatile, has Htde odor, and is extremely toxic. Symptoms of dangerous exposure may not appear for several days. Effective medical treatment should be started immediately. The plant should be designed to ensure containment of nickel carbonyl and to prevent operator contact. 

Skin redness and from slight to corrosive irritation is caused by direct contact. Acryhc acid is more corrosive than esters. The monomers not only irritate the skin, but may also be absorbed through the skin. Therefore, gloves and protective clothing and shoes or boots should be used in addition to eye (or hiU face) protective equipment. Upon contact, the skin should be flushed with copious amounts of water foUow-up medical attention should be sought. Medical attention should also be obtained if any of the earlier mentioned symptoms appear. 

Extreme caution must be taken to prevent the possibility of fire when using flammable removers. Extra care must be taken when stripping on location to secure the area of ignition sources. When used on lacquer finishes, the dissolved finish and remover combined are extremely flammable. Natural mbber, neoprene, or other gloves suitable for use with the remover formula must be worn. The effect of skin contact with the remover is limited because there is immediate irritation and discomfort. Canister respirators are available for most petroleum and oxygenate remover solvents. Symptoms of long-term overexposure should be compared to symptoms of the major ingredients in the formula. 

Mustard and Related Vesicants. Mustard, bis(2-chloroethyl) sulfide [505-60-2] (Chemical Agent Symbol HD), C1(CH2)2S(CH2)2C1, is a colodess, oily hquid when pure. Most samples have a characteristic garliclike odor. It is primarily a vesicant bUsters are formed by either Hquid or vapor contact. Mustard also attacks the eyes and lungs and is a systemic poison, so that protection of the entire body must be provided. It is insidious in its action there is no pain at the time of exposure, and symptoms usually do not appear until several hours after exposure. 

Physiological Effects. The sulfur and nitrogen mustards act first as cell irritants and finally as a cell poison on all tissue surfaces contacted. The first symptoms usually appear in 4—6 h (4). The higher the concentration, the shorter the interval of time between the exposure to the agent and the first symptoms. Local action of the mustards results in conjunctivitis (inflammation of the eyes) erythema (redness of the skin), which may be followed by blistering or ulceration and an inflammatory reaction of the nose, throat, trachea, bronchi, and lung tissue. Injuries produced by mustard heal much more slowly and are much more Fable to infection than bums of similar intensity produced by physical means or by other chemicals. 

Acrylonitrile (Vinyl cyanide) CH,CHCN Closely resembles HCN in toxic action Poisonous by inhalation, ingestion or skin absorption Emits cyanides when heated or contacted by acids or acid fumes Symptoms flushed face, irritation of eyes and nose, nausea etc. Colourless flammable liquid with mild, faintly pungent odour Elash point 0°C. Dilute water solutions also have low flash points... 

Seek medicai treatment when anyone has symptoms apparentiy due to inhaiation or contact with eyes... 

Health Hazards Information - Recommended Personal Protective Equipment Protective clothing should be worn when skin contact can occur. Respiratory protection is necessary when exposed to vapor. Complete eye protection is recommended Symptoms Following Exposure Breathing of vapors... 

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