Contact dermatitis miconazole

The formation of peroxides and formaldehyde in the high-purity polyoxyethylene surfactants in toiletries has been shown to lead to contact dermatitis [31], Peroxides in hydrogenated castor oil can cause autoxidation of miconazole [32], Oxidative decomposition of the polyoxyethylene chains occurs at elevated temperature, leading to the formation of ethylene glycol, which may then be oxidized to formaldehyde. When polyethylene glycol and poloxamer were used to prepare solid dispersions of bendroflumethiazide, a potent, lipophilic diuretic drug, the drug reacted with the formaldehyde to produce hydroflumethiazide [33],... 

Degreef H, Verhoeve L (1975) Contact dermatitis to miconazole nitrate. Contact Dermatitis 1 269-270... 

Alanko K, Jolanki R, Estlander T, Kanerva L (1999) Occupational compound allergy from an industrial grease caused by an oxidation product of phenyl-alpha-naphtylamine. J Eur Acad Derm Venereol 12 Suppl 2 186-187 Aldridge RD, Main RA (1984) Contact dermatitis due to a combined miconazole nitrate/hydrocortisone cream. Contact Dermatitis 10 58-60... 

Attye A, Auger P, Joly J (1990) Incidence of occult athlete s foot in swimmers. Eur J Epidemiol 6 244-247 Baes H (1991) Contact sensitivity to miconazole with ortho-chloro cross sensitivity to other imidazoles. Contact Dermatitis 24 89 Baird JK, Wear DJ (1987) Cercarial dermatitis the swimmer s itch. Clin Dermatol 5 88-91... 

Miconazole was originally marketed only for topical use in a 2% cream, lotion and powder. Allergic contact dermatitis to miconazole has recently been described. De Greef et al. (16 ) noted aggravation in 8 of 108 patients treated with the 2% cream, of whom one had a positive patch test to 2% miconazole. Van Ketel(17 -) described patch tests in one patient with a clinical reaction to the cream after 6 weeks use, with a positive patch test to 2% miconazole in vaseline and negative tests to the related imidazole derivatives mebendazole, tinidazole and metronidazole. 

Van Ketel, W. G. (1974) Allergy to miconazole nitrate. Contact Dermatitis Newsletter, 16, 517. 

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