Contact central nervous system drugs

Sinus problems, hay fever, bronchial asthma, hives, eczema, contact dermatitis, food allergies, and reactions to drugs are all allergic reactions associated with the release of histamine and other autocoids, such as serotonin, leukotrienes, and prostaglandins. Histamine release is frequently associated with various inflammatory states and may be increased in urticarial reactions, mastocytosis, and basophilia. Histamine also acts as a neurotransmitter in the central nervous system (CNS). Upon release from its storage sites, histamine exerts effects ranging from mild irritation and itching to anaphylactic shock and eventual death. 

This chapter discusses specific organ systems that contact a variety of substances in the workplace environment (or due to drug abuse and addiction), leading to health hazards. Important organs discussed here include the skin, the respiratory system, the cardiovascular system, the renal system, and the central nervous system (CNS). In the United States and other countries of the world, the application of phenol is on the increase in the manufacture of aromatic compounds, explosives, fertilizers, paints, rubber products, wood preservatives, synthetic resins, drugs and pharmaceutical products, plastics, leather tanning and... 

Only one of these therapeutic uses has turned out to be valid, and that is the use of cocaine as a local anesthetic. When cocaine makes direct contact with peripheral neurons, it prevents neural firing, which has the effect of numbing the area. This action is unlike cocaine s effects on the central nervous system. Cocaine was the first local anesthetic and revolutionized surgery. Now, of course, related -caine drugs such as procaine and xylocaine are used more frequently, but because cocaine also constricts blood vessels, it is still used for surgery on areas such as the face, due to the fact that it reduces bleeding as well as pain. 

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