Connection meaningful

A typical molecular dynamics simulation comprises an equflibration and a production phase. The former is necessary, as the name imphes, to ensure that the system is in equilibrium before data acquisition starts. It is useful to check the time evolution of several simulation parameters such as temperature (which is directly connected to the kinetic energy), potential energy, total energy, density (when periodic boundary conditions with constant pressure are apphed), and their root-mean-square deviations. Having these and other variables constant at the end of the equilibration phase is the prerequisite for the statistically meaningful sampling of data in the following production phase. 

In order to indicate the hierarchical position of a section, the top of every page of text shows the headings of up to three connected sections that are superior in hierarchy. These running heads provide the context within which the title of the section under discussion becomes meaningful. As an example, the page of Volume 1 on which section 1.4.9.1.3 in the Production of Methanol starts, carries the running heads ... 

Information access breakdowns occur when pertinent information has been stored but it either cannot be accessed for technical reasons or for some reason cannot be found in a meaningful or expedient manner for a particular application. Technical reasons can include legacy databases that are not connected with current systems, incompatibility issues between systems, problems of localized access (information can only be accessed within a site, a group or domain area, or even a personal computer), and authentication (people do not have the required authority to access information they need or cannot remember usernames and passwords). 

Catalytic activity of solid acids in hydrocarbon conversions is often correlated with their acidity. Problems arise from the difficulty to bridge the gap between the equilibrium thermodynamic concept of acidity and the composite kinetic concept of catalytic activity [1], The correlation is meaningful if connected parameters are related to each other, namely, intrinsic activities are correlated with intrinsic acidities or relationship is established between corresponding apparent parameters. 

Where die connection between a vitamin and a disease is less transparent, a wide field remains open for the discovery of meaningful correlations between vitamin content of body fluids and tissues and physiologic or pathologic events. 

There may also be circumstances where a categorisation combines responses measured, on different domains of action for example to give a single dichotomous responder/non-responder outcome. There are connections here with global assessment variables. This approach is taken in Alzheimer s disease where the effect of treatment is ultimately expressed in terms of the proportion of patients who achieve a meaningful benefit (response) see the CPMP (1997) Note for Guidance on Medicinal Products in the Treatment of Alzheimer s Disease . In oncology. 

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