Conjugated linoleic acid isomers activity

Bretillon, L., Chardigny, J.M., Gregoire, S., Berdeaux, O., Sebedio, J.-L. 1999. Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. Lipids. 34, 965-969. 

Pariza, M.W., Park, Y., and Cook, M.E. 2001. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40(4) 283-298. 

Conjugated linoleic acid (CLA) has attracted much interest recently, due its potential anti-cancer, anti-atherogenic and anti-inflammatory therapeutic properties (Weiss et al., 2004 see Chapter 3). CLA occurs as several positional and geometric isomers of Ci8 2 with a conjugated double bond. The cis-9, tram-11 CLA isomer occurs most often naturally. Commercial sources of CLA also contain the trans-10 and cis-12 isomer, which is also biologically active. Since various isomers of CLA differ in biological activity, methods of analysis for the various CLA isomers have become very... 

Over the last two decades, the conjugated fats and, particularly, conjugated linoleic acid (CLA) have been intensively studied for their biological activity. As a result of the ease of synthesis, blends of two CLA isomers, namely 9,11-ct and 10,12-tc-CLA, have been the focus of most research into biological activity. Recent research, however, has been expanding to include pure or enriched isomer preparations. 

Choi, Y., Park, Y., Storkson, J.M., Pariza, M.W., and Ntambi, J.M. 2002. Inhibition of stearoyl-CoA desaturase activity by the cis-9, trans-11 isomer and the trans-10, cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. Biochem. Biophys. Res. Com. 294, 784-790. 

Conjugated linoleic acids (CLAs) have been reported to be antitumoral fatty acids [9,10]. Two types of biologically active CLAs are known the cis-9,trans-ll isomer and the trans-l0,cis-l2 isomer. The former is the principal dietary form of CLA and was used in our experiment as a reference. Comparisons of cytotoxicity to breast cancer cells revealed that the cytotoxicity of 13-MTD was almost equivalent to that of CLA. 

Palombo JD, Ganguly A, Bistrian BR, Menard MR (2002) The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Lett 111 163-172. 

Isomers of conjugated linoleic acids (CLA) have anticancer activity, and immnne-enhancing-weight reductions, and antiatherogenic properties. CLA are fonnd in food prodnced from ruminant animals. The development of CLA-enriched eggs showed a redaction in monoenoic FA and non-CLA PUFA after CLA feeding, and an increase in ERA and DHA. The incorporation rates of different CLA isomers into the whole lipids of egg yolk and TAG, PC, and PE-lipid classes were different. cis-9,trans-ll and cis-l0,trans-l2 CLA were deposited more in TAG, bnt cis-11,trans-l3 CLA was less. There are large differences in the concentrations of cis-8,trans-10 CLA in PC and PE (Table 14.10C). 

Bulgarella, J.A., Patton, D., and Bull, A.W. (2001) Modulation of Prostaglandin H S5mthase Activity by Conjugated Linoleic Acid (CLA) and Specific CLA Isomers, Lipids 36,407-412. 

Choi, Y, Y. Park, M.W Pariza, and J.M. Ntambi. Regulation of Stearoyl-CoA Desaturase Activity by trans- 0,cis- 2 Isomer of Conjugated Linoleic Acid in HepG2 cells,... 

Desaturase Activity by m-9, trans- and the rr< w-10, cm-12 Isomer of Conjugated Linoleic Acid in MDA-MB 231 and MCF-7 Human Breast Cancer Cells,... 

There are two known biologically active isomers of conjugated linoleic acid (CLA) c9, llCLA, the most prevalent CLA isomer in the diet, and tl0,cl2 CLA, which appears to induce most of the known physiologic effects attributed to CLA, particularly as they relate to fat storage and metabolism (1,2). Important examples are the inhibition of body fat accretion seen in many animal species fed diets containing CLA, and inhibition of milk fat synthesis in dairy cows, effects that are induced by the tl0,cl2 CLA isomer (3-5). 

Palombo, J.D., Ganguly, A., Bistrian, B.R., and Menard, M.P. (2002) The Antiproliferative Effects of Biologically Active Isomers of Conjugated Linoleic Acid on Human Colorectal and Prostatic Cancer Cells, Cancer Lett. 177,163-172. 

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