Congeneric groups

Until very recently apomorphine (APO) was the only important chiral DA agonist whose enantiomers had been studied. The only congeneric groups of resolved agonists to be reported subsequently were 2-aminotetralins 1, 2 ). The present enantiomer study of the SK F 38393 series thus provides welcome new data for stereochemical definition of DA receptors. Moreover, the previous studies employed rather narrow choices of pharmacological models. The broader range of models presented here is therefore particularly helpful. 

Safety Considerations for Essential Oils, Constituents, and Congeneric Groups.237... 

Safety of Constituents and Congeneric Groups in Essential Oils.238... 

Organization of Chemical Data Congeneric Groups and Classes... 

FIGURE 8.1 Congeneric groups are formed by members sharing common structural and metabolic features, such as the group of 2-isopropylidene-substituted cyclohexanone derivatives and related substances. 

Specify the mean of concentrations for congeneric groups with con dence limits that constitute a suf cient number of commercial lots constituting the vast majority of the oil. 

In Steps 5,6, and 7, each congeneric group in the essential oil is evaluated for safety in use. In Step 5, an evaluation of the metabolism and disposition is performed to determine, under current conditions of intake, whether the group of congeneric constituents is metabolized by well-established detoxication pathways to yield innocuous products. That is, such pathways exist for the congeneric group of... 

In the event that insuf cient data are available to evaluate a congeneric group at Step 7, or the currently available data result in margins of safety that are not suf cient, the essential oil cannot be further evaluated by this guide and must be set aside for further considerations. 

Use of the guide requires scienti c judgment at each step of the sequence. For instance, if a congeneric group that accounted for 20% of a high-volume essential oil was previously evaluated and found to be safe under intended conditions of use, the same congeneric group found at less than 2% of a low-volume essential oil does not need to be further evaluated. 

In corn mint oil, the principal congeneric group is composed of terpene alicyclic secondary alcohols, ketones, and related esters, as represented by the presence of (-)-menthol, (-)-menthone, (+)-isom-enthone, (-)-menthyl acetate, and other related substances. Samples of triple-distilled commercial... 

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