Conformation, capsular polysaccharides

Fig. 27 a, b. Tetrasaccharide with two repeating disaccharide units from Klebsiella capsular polysaccharide K23 in its two energetically favored conformations... 

In V. Cholerae, the Galp residue carries a 4,6-cyclic phosphate. The same repeating unit was found in the capsular polysaccharide. Multidimentional he-teronuclear NMR and molecular-modeling studies showed that the 0139 tetrasaccharide adopts a compact and tightly folded conformation that is relatively rigid and similar to the Leb conformation. The cyclic phosphate on the (3-galactopyranoside residue is in contact with the colitose residue linked to (3-GlcNAc.209 The capsular polysaccharide has been proposed as the basis for vaccine development.210... 

Structure and Conformation of the Capsular Polysaccharides of Group B Streptococcus... 

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