Condylomata acuminata genital

In refractory condylomata acuminata (genital warts), intralesional injection of various IFNs is associated with complete clearance in 36-62% of patients, but other treatments are preferred. Relapse occurs in 20-30% of patients. Verruca vulgaris may respond to intralesional IFN-CC. Intramuscular or subcutaneous administration is associated with regression in wart size but greater toxicity. Systemic IFN may provide benefit in recurrent juvenile laryngeal papillomatosis and laryngeal disease in older patients. 

Condylomata acuminata (genital warts) are sexually transmitted benign neoplasms caused by the human papilloma virus (HPV) that may involve the vulva, vagina. 

Genital warts (condylomata acuminata) Topical Apply 0.5% solution or gel ql2h in the morning and evening for 3 days, then withhold for 4 days. Repeat cycle up to 4 times. 

Genital warts (condylomata acuminata) Topical Apply 10% 25% solution in compound benzoin tincture to dry surface. Use 1 drop at a time allowing drying between drops until area is covered. Total volume should be limited to less than 0.5 ml per treatment session. 

IFN-a may be used for the treatment of condylomata acuminata (venereal or genital warts), malignant melanoma, hairy cell leukemia and hepatitis B and C, and other types of cancer including skin, kidney and bone cancers. 

Imiquimod is an immune response enhancer that induces production of interferon and several other cytokines. It is used, in formulations containing 5%, to treat external genital and perianal warts/condylomata acuminata in adults (1). As imiquimod-treated warts regress, serum concentrations of interferon-alfa, interferon-beta, interferon-gamma, and tumor necrosis factor rise (2). Trials of imiquimod have failed to identify any particular systemic or laboratory abnormalities. 

Molecular biological methods employing hybridization have identified more than a dozen types of viruses in topical genital condylomata acuminata [59,60]. 

L. Gissmann, H. zur Hausen (1980). Partial characterization of viral DNA from human genital warts (Condylomata acuminata). Int. J. Cancer, 25(5), 605-609. 

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