Concordant indicator

Based on equations 11.79 and 11.80, the measured P b/sr value for each mineral of a given isochron must furnish concordant indications in terms of the T and P of equihbrium. Moreover, the deduced parameters can be assumed to correspond to the condition of closure of exchanges. 

The ages of all samples are sufficiently concordant, indicating that they formed within a relatively short interval of time (about 90 Ma) ... 

Records kept on the effectiveness of the work with the inmates at Concord indicate that, over a five-year period, more than twice the usual number of men have been able to stay out of prison after their release. The significance of these, however, is sharply reduced by the lack of a control group of inmates, which should have received an equal amount of attention from us while not using psilocybin. 

Synonym Thymoxamine hydrocholride Trade names Erecnos Icavex Opilon (Concord) Indications Impotence, primary Raynaud s phenomenon Category Alpha-adrenergic channel blocker Half-life 1-2 hours... 

The weighted sum of individual concordance indices is calculated to determine the global concordance index when comparing solution i to solution j. 

In an experiment to determine the percentage of nickel In hydrated nlckel(ll) sulfate, 2-63 g of the nlckel(ll) sulfate were weighed accurately, dissolved In water and diluted to 100 cm in a standard flask. A 20-0 cm volume of this solution was pipetted Into a conical flask along with an indicator solution. This solution was titrated against a 0-100 mol fi EDTA solution until the end-point was observed. The titrations were repeated until concordant results were obtained. 

A 1-50 g mass of aspirin was hydrolysed with 25-0 cm of 1-00 mol NaOH solution. After the hydrolysis was complete, the reaction mixture was transferred, with rinsings, to a 250 cm standard flask and made up to the graduation mark with distilled water. The solution was mixed thoroughly and 25-0 cm was pipetted Into a conical flask, along with a few drops of phenolphthalein Indicator. This was titrated with 0-0500 mol sulfuric add solution until the end-point of the titration was Indicated by the colour change from pink to colourless. The titrations were repeated until concordant results were obtained. 

The results are In concordance with published Information available regarding coating deterioration. It was confirmed that a fall In R( t as well as the appearance of Warburg-type of behavior at low frequencies, especially at higher temperatures, is clearly an Indication of lack of protection, A properly prepared surface... 

Repeat-dose toxicity studies should be performed in a rodent, typically the rat, and a non-rodent. The longer the duration of human exposure, the longer must be the duration of the toxicity studies. The ICH guideline indicates that for Phase I and Phase II studies, the clinical duration can equal the duration of the toxicity studies in all regions. This concords with the UK guidelines revised by the Medicines Control Agency (MCA) in December 1995. ... 

Predictive High sensitivity and specificity and concordance with in vivo toxicity in species designed to be indicative of inhibitor of DNA polymerize gamma for mitochondrial DNA synthesis by nucleoside reverse transcriptase inhibitors... 

Evidence-based pharmacotherapy provides a succinct appreciation of the benefits of a drug, but rarely takes into account the patient s quality of life. Eor instance, intensive statin therapy is recommended because it reduces the incidence of cardiovascular death (odds ratio 0.86), myocardial infarction (odds ratio 0.84), and stroke (odds ratio 0.82) however, the increased risks for any adverse event (odds ratio 1.44), for abnormalities on liver function testing (odds ratio 4.48), for elevations in CK (odds ratio 9.97) and for adverse events requiring discontinuation of therapy (odds ratio 1.28) are less often taken into account by the prescriber. This example emphasises that individualisation is of the utmost importance to keep an acceptable benefit/risk ratio (Clin Ther 2007 29 253-60). The benefits of evidence-based pharmacotherapy may be obtained whenever concordance/compliance of the patient is adequate. However, concordance rate is slightly higher than 30% for chronic conditions, such as hypertension (Curr Hypertens Rep 2007 9 184-9), indicating that the patient has to be educated about the use of drugs, and therapy has to be individualised. 

Menaker You are focused on methods of analysis here. But it seems to me that if you are going to try to get concordance among experiments from different laboratories, you really have to worry about the conditions of the experiments. Michael Rosbash showed us nice data indicating that damped oscillations can grow in constant darkness in some of the cells. If you take this seriously, and you are trying to compare data sets that were generated after 1 d DD with those generated after 3 d DD, there is a problem. 

Specific reviews of the electrochemistry of mononuclear carbonyls have not appeared. The primary oxidation of the mononuclear carbonyls leads to the formation of 17-electron radical cations with half-lives in the order of seconds or less in MeCN electrolytes [14, 15]. Decay may take place by disproportionation, CO loss, and/or nucleophilic attack. Electrogeneration in solvents of low nucleophilicity such as trifluoroacetic acid can enhance the stability of the cations and indicates that nucleophilic attack is a major pathway for decay. This is concordant with the stability order [Cr(CO)g]+ > [Fe(CO)5]+ [Ni(CO)4]+, where the lower coordination numbers favor nucleophilic attack and... 

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