Conclusions and Suggestions for Further Work

Before the chemistry of the 1,6-disubstituted triptycenes can be developed much further, a -good, general method is required for their synthesis. One possible route to the Group V triptycenes which has not been explored is to treat alkali or alkaline earth pnictides with aryl halides  

What happens to the boron stereochemistry and the molecular stability when attempts are made to remove the ammonia by reacting the diadduct with a stronger Lewis acid  

In this way triptycenes could perhaps be used to explore the chemistry of severely nonplanar Group III elements. 

As is obvious from this review the subject of 1,6-disubstituted triptycenes is very much in its infancy, but it is hoped that new workers will be attracted to the field, bringing with them fresh ideas and expertise spawned in other areas of research. 

CYSTEINE-CONTAINING OLIGOPEPTIDE MODEL COMPLEXES OF IRON-SULFUR PROTEINS 

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VIII. Conclusions and Suggestions for Further Work References... 

The conclusion of the presentation normally consists of a brief summary of the key points and a list of recommendations, including suggestions for further work. 

A list of specific suggestions on how to improve the quality of the work reported is appropriate after the section of conclusions. These recommendations should address items such as experimental design, equipment modifications, sample collection systems, need for further work, and so on. Conclusions and Recommendations may conform into a single section. 

As a consequence of this conclusion, we are immediately faced with the necessity of looking for other explanations of the deviations from Gaussian behaviour than anisotropic excluded volume effects. We, therefore, turn to the suggestion of further structuring in the network made originally by Gee, and worked out subsequently by Volkenstein, Gotlib and Ptitsyn (774), and more recently by Blokland (74). 

The present observations could well be explained on the same basis since hexamethylcyclotrisiloxane polymerizes via both anionic and cationic mechanisms (5). (No evidence exists to date for free radical polymerizations.) The greater activity of H2O as an inhibitor, as compared with NH3, is explained on the basis of a more rapid ion transfer. Since this would be a hydrogen ion rather than a hydride ion, it further suggests an anion as the primary polymerization species in the present polymerization. The authors feel, however, that further work is required before definite conclusions can be drawn regarding the polymerization mechanism or mechanisms. 

Evidence from in vivo experiments after administration of hCG suggested that a lesion develops between the LH receptor and the adenylate cyclase in rat testis cells and ovarian cells (see Ref. 69 for other references). Further work carried out in vitro with tumour Leydig cells demonstrated that LH produced a decrease in LH stimulation of adenylate cyclase in intact cells. This loss of response persisted in plasma membranes prepared from the desensitized cells [70]. The response of the intact cells to cholera toxin and of the plasma membranes to fluoride and p(NH)ppG were not decreased. These studies suggested that the lesion occurred between the LH receptor and Gs, whereas the coupling between Gs and the adenylate cyclase catalytic unit was intact. Such a conclusion is in agreement with that of other workers investigating the catecholamine-induced desensitization of S49 lymphoma cells [71,72], This lesion may be necessary before internalization of the receptor can occur. 

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