Conclusion The Possible Role of Iron in Neurodegeneration

It is important to stress that Mossbauer spectroscopy did not detect any divalent iron in all the samples measured. In a study using analytical transmission electron microscopy, the authors suggested that iron within the ferritin core in pathological SN and HP was present mainly as mixed ferric-ferrous iron oxides (magnetite-like or wiistite) and not as ferrihydrite that is the main mineral in control brain ferritin [31 ]. Mossbauer spectra of magnetite or wiistite differ from ferrihydrite spectra, but only ferrihydrite-like spectra were observed by MS in all pathological tissues. If other phases were present, they could be there only in minor quantities. 

Lauffer, ed.. Iron and Human Disease, CRC Press, Boca Raton, 1992. 

Gatgzka-Friedman, E.R. Bauminger, A. Friedman, M. Barcikowska, D. Hechel, I. Nowik, Alov. Disord 1996, II, 8-16. 

Galazka-Friedman, E.R. Bauminger, K. Szlachta, K. Schweitzer, Z. Wszolek, D. Dickson, A Friedman, Acta. Phys. Pol. 2009, / IS, 431-433. 

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