Compounds Containing Carboxylic Groups

Compounds containing carboxyl groups on adjacent carbons (succinic acid derivatives) can be bisdecarboxylated with lead tetraacetate in the presence of O2 263 jjjg reaction is of wide scope. The elimination is stereoselective, but not stereospecific (both meso- and dl- 2,3-diphenylsuccinic acid gave trans- stilbene) a concerted mechanism is thus unlikely. The following mechanism is not inconsistent with the data ... 

In this paper we describe some of our work on a study of the effects of gamma radiation on a variety of polycarboxylic acids and a related series of small molecule, model compounds containing carboxyl groups. 

Chapter VIII. Arsenical Compounds containing Carboxyl Groups. . . ... 

There are many pharmaceutical preparations and biological compounds containing carboxylic group, i.e., fatty acids, prostaglandins, steroids, bile acids, a-keto acids, and glucuronic acid. These compounds play important physiological roles to achieve homeostasis. 

A TETRACRGAHOTIN COMPOUNDS CONTAINING CARBOXYL GROUPS AND DERIVATIVES... 

Listing tetraorganotin compounds containing carboxylate groups continues in Table II5. 

Table 115. Tetorganotin Compounds Containing Carboxyl Groups and Derivatives... 

Nontoxic ahphatic compounds containing carboxyl, ester, or hydroxyl groups are readily biodegradable. Those with dicarboxyhc groups require longer acclimation times than those with a single carboxyl group. 

Porphyrins containing carboxyl groups have been esterified with B HuSH2-(Scheme 2.2-22). The compounds show rather long retention times in the body, as is anticipated from other porphyrins. The toxicity of porphyrins is, however, a problem [68],... 

The described procedure is useful for the preparation of a wide variety of compounds containing trifluoromethyl groups from the corresponding carboxylic acids.8 The yields are generally 60-90%. Some representative examples are listed in Table I. In the cases of the difunctional acids, only 0.1 mole of the compound should be used in the procedure. 

The mechanism of carbodiimide-mediated amide formation is outlined in Figure 13.4. The first intermediate formed during the reaction of a carbodiimide with a carboxylic acid (or an ammonium carboxylate [56]) is an O-acylisourea [1]. Under acidic conditions [57,58], this intermediate reacts with acids to yield anhydrides, and with alcohols, phenols, HOBt, or other compounds containing hydroxyl groups, to yield the corresponding esters. The carbodiimide is thereby transformed into a urea. 

Reaction LXVI. (a) Redaction of Unsaturated Acids by means of Sodium Amalgam in Alkaline Solution. (A., 121, 375 137, 237.)—The preparation below illustrates an important application of sodium amalgam, this substance being especially useful for reducing groups or double bonds in compounds containing carboxyl, as the alkali present keeps the substance in solution and protects the acid group. 

Vancomycin has been used widely for enantiomeric resolution as it is very effective for the enantiorecognition of anionic compounds, particularly those containing carboxylic groups in their structure. The selectivity toward these... 

Compounds containing functional groups that can be converted to carboxylic acids by acidic or basic hydrolysis, (p. 981)... 

Generally, in the case of acidic compounds (compounds containing carboxylic acid groups) (e.g., 2,4-D), experiments have shown that adsorption will begin when the pH of bulk solution is approximately 1-1.5 pH units above the pKa of the compound and... 

Compounds such as tri" -(l-aziridinyl)ethyl trimellitate react with carboxyl - ended Butadiene polymer, ank might well be an additive to latices containing carboxyl groups. The original specification quotes 24 hours stoving at 85°. (50).See also(54)... 

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