Compound storage

Repeating for emphasis - not aU poorly water-soluble compounds are equally solubilized by DMSO. The greaseball compounds will be much better solubilized than the brickdust compounds. The most common range of compound in DMSO stock concentrations in compound storage repositories is 2-20 mM. At conferences, organizations employing 2mM compound in DMSO stock solutions report fewer solubility problems. The downside is that the lower stock concentrations are more Hmited in utility in some absorption, distribution, metabolism, excretion and toxicity assays that require higher compound concentration. 

DMSO Compound Storage Stocks and Compound Integrity... 

Mention has previously been made of the traditional analytical expertise in quantitating chemical degradation. What is not commonly known is that there are two business reasons for studying chemical degradation attendant to compound storage. In the first business reason the compound store is considered as inventory, and corporate policies and procedures relevant to inventory apply, e.g. inven-... 

The type of solution being prepared dictates the methods of compounding, storage, and infusion. The two most common types of PN solutions are 2-in-l solutions with or without IVFE piggybacked into the PN line, and TNAs. 

Methods for compounding PN solutions vary among institutions and often involve automated compounders. Sterility should be assured during compounding, storage, and administration. 

The implementation of efficient and updated 2D and 3D structure databases is one major challenge in molecular diversity management. In addition to the compound design and selection criteria used for the compilation, the quality of the compound storage, manipulation, and logistics systems used for the management of the collection are key factors to yield reproducible results. ... 

As for container material, polypropylene containers are as satisfactory as glass ones in compound stability and recovery. Since water is more harmful than oxygen to compound degradation and the hygroscopic nature of DMSO favors water uptake, humidity control is a key parameter to ensure compound storage stability. 

Fayez, H., Morin, J., and Paslay, J. 2008. Compound storage evolution unlocking the right combination. Drug Disc. World 9, 62-68. 

FIGURE 14.9 Integration of inventory system with other components of operational informatics environment (right) and with compound storage and retrieval system (CSRS) and plate and sample manipulation instrumentation (left). 

Integration with Compound Storage and HTS Robotics Instrumentation... 

The Poisons Act 1952 (revised 1989) regulates the importation, possession, manufacture, compounding, storage, transport, sale and use of poisons. Essentially, the act determines whether a pharmaceutical product is a prescription item, a pharmacy-only item or an over-the-counter (OTC) item. The classification of a pharmaceutical product into the various categories is the function of the Poisons Board whose secretariat is placed at the offices of the Director of Pharmaceutical Services. The Director of Pharmaceutical Services is also the competent authority for the issuance of import and export authorisation of psychotropics under the Convention on Psychotropic Substances 1971. 

Stock solutions allow ease of compound storage and distribution and as such they are particularly amenable to plate-based formats. 

Both chemistry and biology have converged on a common 96-well format as a convenient means of combinatorial synthesis, purification, compound storage, and drug screening. The development of assay plates with the same footprint but increasingly high density arrays (e.g., 384, 864, and 1536) has... 

Yaskanin, D. Quality Perspectives for Compound Storage, presented at the Drug Discovery Technology World Congress post-conference session on Repository Compound Stability Studies, Boston, MA, August, 2002. 

Compound Storage For the storage of low volumes (typically 6 pL per well) over... 

Fig. 4. Compound storage, (a) Scheme of the Novartis/Greiner 1536w COC storage plate, (b) Evaporation profiles of a source plate audited after loading and (c) after 3 months storage. Less than 1 gL volume loss was detected in the corner wells. Each point represents a well volume at the time of the audit.

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