Repository compounds

Cheng X, Hochlowski J, Tang H, etal. (2003) Studies on repository compound stabihty in DMSO under various conditions. J. Biomol. Screen. 8 294—304. 

Cheng X, Hochlowski J, Tang H, Hepp D, Beckner C, Kantor S, 60. Schmitt R. Studies on repository compound stability in DMSO under various conditions. J. Biomolec. Screen. 2003 8 292-304. Kozikowski BA, Burt TM, They DA, Williams LE, Kuz- 61. mak BR, Stanton DT, Morand KL, Nelson SL. The effect of room-temperature storage on the stability of compounds in DMSO. J. Biomolec. Screen. 2003 8 205-209. 

Cheng X, Hochlowski J, Tang H, Hepp D, Beckner C, Kan tor S, and Schmitt R. Studies on Repository Compound Stability in DMSO under Various Conditions./BiomoZ Screen 2003 8 292-304. 

Hochlowski, J. Cheng, X. Sauer, D. Djuric, S. Studies of the Relative Stability of TFA Adducts vs. non-TFA Analogues for Combinatorial Chemistry Library Members in DMSO in a Repository Compound Collection, J. Comb. Chem. 5, 345-349 (2003). 

Heaton, Z. A Summary of Stability Experiments Carried Out at GlaxoSmithK-lein, presented at the Drug Discovery Technology World Congress postconference session on Repository Compound Stability Studies, Boston, MA, August, 2002. 

As is common practice, repository compounds are stored either in the solid state or in solution at nominally mM concentrations. It is generally... 

Factors intrinsic to the nature of the repository compound samples such as structure, physical/chemical properties, salt form, the presence of other... 

X. Cheng, Post DDT2002 session on Repository Compound Stability Studies, Boston (2002). 

Among the various approaches, major emphasis has been directed toward the development of parenteral repository or depot antimalarial substances. Such preparations consist typically of suspensions of repository compounds in aqueous or lipid vehicles. When these suspensions are injected intramuscularly or subcutaneously, the insoluble material is deposited in the tissues, forming a depot from which active principles are very slowly released into the circulation. In preparations of this type, it is essential that candidate substances be nonirritating to the tissues and imdergo minimal encapsulation. 

Fic ure 4 Chemical spaceanalysisplot of cyclooxygenase-1 inhibitors (diamonds) and MDLDrug Repository compounds (triangles), created using chemical descriptors and principal component analysis. Plot shows that the cyclooxygenase-1 inhibitors occupy a fairly broad area of chemical space. 

---