Compound Society Library

Though a search dealing with an organic compound may start with the formula index of Chemical Abstracts, while one on an industrial engineering problem may begin in the Engineering Societies Library in New York City, the same basic principle of searching is involved—namely, key terms are looked up in the most appropriate sources. 

The bioanalytical revolution continues in fact, the drug discovery revolution continues inexorably forward. Today, not only are humans benefiting from revolutionary new medicines that have dramatically improved the quality of life, but more is expected to come. Compound collections have ballooned through combinatorial library synthesis biological science has mapped the human genome, and society impatiently awaits the promise of genetically tailored medicines that will treat virtually every ailment. 

Griffith MC, Dooley CT, Houghten RA, Kiely JS, Solid-phase synthesis, characterization, and screening of a 43,000-compound tetrahydroisoquinoline combinatorial library, in Molecular Diversity and Combinatorial Chemistry (Eds Chaiken IW, Janda KD), pp. 50-57, 1996, American Chemical Society, Washington. 

In conclusion, the Authors wish to thank the Editor, Dr. J. Newton Friend, for his invaluable help in reading the whole of the manuscript and proofs, to Messrs. Flack and Smith of the Library of the University of Birmingham, for giving the Authors free access to any portion of the Library, and to E. Masters, B.Sc., A.R.C.S., for lending the Authors his copies of the Journal of the American Chemical Society. Reprints of original papers dealing with organometallic compounds will be thankfully received by the Authors. 

Source Reproduced with permission from Zhang W., Luo, Z, Chen, C. H.-T. Curran, D. Solution-Phase Preparation of A 560-compound library of individually pure mappicine analogs by fluorous mixture synthesis, J. Am. Chem.Soc. (2002) 124, 10443-10450. Copyright (2002) American Chemical Society.)... 

Xu R, Cai Z, Fogelman K, Wikfors R, Worle V, Stublen N, Kassel DB. Mass-directed purification of compound libraries by automated semi-preparative SFC/MS. Oral presentation and poster. American Society for Mass Spectrometry. Orlando, FL, 2002. 

One of the most positive identification methods of an organic compound is to find a reference IR spectrum that matches that of the unknown compound. This approach is facilitated using spectral libraries as compiled by various societies or... 

C. J. Evans and S. Karpel. Organotin Compounds in Modem Technology, Journal of Organometallic Chemistry Library, 16 Elsevier, Amsterdam, 1985, 280 pp. S. J. Blunden, P. a. Cusack and R. Hill, The Irulustrial Uses of Tin Chemicals, Royal Society of Chemistry, London, 1985, 346 pp. K. Das, S. W. Nc and M. Gielen, Chemistry and Technology of Silicon and Tin, Oxford University Press, Oxford, 1992, 608 pp. 

R.D. Cramer, D.E. Patterson and P. Hecht, Discovery and lead refinement using Chemspace (TM), Abstracts of papers of the American Chemical Society, 215 016-COMP, Part 1 APR 2 1998 Virtual compound libraries a new approach to decision making in molecular discovery research J. Chem. Inf. Comp. Sci. 38 (1998), 1010-1023. 

With the advent of accurate mass instruments, access to a reference database or library of compounds with the exact masses of precursor and product ions is becoming increasingly important. Many instrument manufacturers, as well as independent companies or institutions, are developing software that allows chemists to manage this type of information for specific applications such as proteomics or chemical contaminants. Examples of online resources that may be useful for searching for unknown residues based on molecular formulas obtained from accurate mass data inciude Metlin from the Scripps Center for Mass Spectrometry and ChemSpider from the Royal Society of Chemistry. " ... 

Figure 8.17 N-CrkSH3 peptoid hit compounds identified from selection of a 100-million library. Re-assayed activities (top to bottom) 16 pM, 59 pM, 60 pM, 61 pM, 75 pM, 97 pM. Reprinted, with permission, from Wrenn et al. 2007 American Chemical Society.

Following Emil Fischer s death in 1919, the German Chemdrail Society estabhshed the Emil Fischer Memorial Medal. In 1952, Fischer s oldest son dedicated the Emil Fischer Library, containing his father s books and reference compounds, at the University of California at Berkeley. 

Virshup, A.M., Contreias-Garda, J., Wipf, P., Yang, W., and Beiatan, D.N. (2013) Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds. Journal of the American Chemical Society, 135, 7296-7303. 

Figure 14.12. Rosamine compounds as fluorescent probes, (a) Solid-phase library synthesis (b and c) diverse applications of rosamine sensors derived from image-based live cell and organism screenings. Reproduced with permission from Refs 53, 54, and 56. Copyright 2007-2010 American Chemical Society Reproduced by permission of The Royal Society of Chemistry. Ref 57. (Seethe color version of this figure in Color Plates section.)...

The Chemical Society (London) annual reports on the progress of chemistry, the Organometal Chemistry periodical report, Freund s Tel 4viv Reviews of Si, Ge, Sn and Pb compounds, and above all the annual surveys of the J. Organometal. Chem. Library (formerly J. Organometal. chem.) yield the most extensive information on organosilicon publications. The latter... 

The unique registration number of a chemical compound or substance assigned by the Chemical Abstract Service, a division of the American Chemical Society. The intention is to make database searches more convenient, as chemicals often have many names. Almost all molecule databases today allow searching by CAS number. The CAS no. usually is given in the substance entries of many library mass spectra. 

Stein SE and Scott DR (1994) Optimization and testing of mass spectral library search algorithms for compound identification. Journal of the American Society of Mass Spectrometry 5 859-866. 

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