Complement factor H

Bladder tumor-associated antigen (BTA), a human complement factor H, is produced by bladder cancer cells (men two to three times as often as women). Cancer cells are sometimes seen in urine samples by microscope cytoscopy (examination of the bladder with an instrument inserted into the urethra), which can reveal abnormal areas. Biopsy is needed to confirm the diagnosis. Early stage cancer confined to the bladder wall can often be removed with a cytoscope. If several tumors are present, they are removed by infusing the bladder with a solution containing bacteria able to stimulate the immune system. 

Chen, M, Forrester, JV, and Xu, H, 2007. Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res 84, 635-645. 

Wiggs, JL, 2006. Complement factor H and macular degeneration—The genome yields an important clue. Arch Ophthalmol 124, 577-578. 

Complement factor H and platelet-activating factor acetylhydrolase polymorphisms and hemolytic uremic syndrome due to E. coli 0157... 

Ying L, Katz Y, Schlesinger M et al. Complement factor H gene mutation associated with autosomal recessive-atypical hemolytic uremic syndrome. Am J Hum Genet 1999 65[6] 1538—1546. 

Klein RJ, Zeiss C, Chew EY et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005 308 385-389. 

Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddme M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Peiicak-Vance MA (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308 419 21. 

Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JR Mane SM, Mayne ST, Bracken MB, Fenis FL, Ott J, Barnstable C, Hoh J (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308 385—389. 

Pandiripally V, Wei L, Skerka C et al. Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci. Infect Immun 2003 71(12) 7119-7128. 

Ram S, McQuillen DP, Gulati S et al. Binding of complement factor H to loop 5 of porin protein lA a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae. J Exp Med 1998 188 671-680. 

Weismann, D., Hartvigsen, K., Lauer, K. N., Bennett, K. L., SchoU, H. P., Charbel Issa, P., Cano, M. et al. Complement factor H binds malondialdehyde epitopes and protects Ifom oxidative stress. Nature 478 2011 76-81. 

Complement Factor H (CFH) or simply Factor H is one of the main inhibitors of the alternative complement pathway and acts both in plasma and on cell surfaces by binding C3b. Binding of CHF to malondialdehyde (MDA) epitopes was demonstrated for necrotic and apoptotic cells as well as for apoptotic blebs. CFH-MDA-adduct complexes bind to C3b and generate locally the anti-inflanunatory iC3b fragment. CHF binding of MDA-adducts can inhibit IL-8 and TNFa production. ... 

Cano, M. et al. 2011. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress, 478, 76-81. 

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. 109> 13757-13762. 

SUN G, LI H, WANG Y, ZHANG B, ZHANG s (2010), Zebiafish Complement factor H and its related genes identification, evolution, and expression , Funcf Integr Genomics, 10,755-87. 

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