Comparison with other Agents

When examined together, these values provide mathematical profiles of the drugs we studied and allow numerically precise comparisons with other agents. The use of operational definitions not only makes it simpler to characterize a drug, but allows accurate predictions of its effects at various doses. Obviously, such predictions have practical as well as academic significance. 

Outpatient anaesthesia. Early recovery is slow and more fluctuant in comparison with other agents. The advent of newer agents, such as propofol, with much more rapid and clear-headed recovery significantly, has reduced the role of thiopentone in outpatient anaesthesia. 

Visco, D., Girard, Y., Prasit, P., Zamboni, R., Rodger, I.W., Gresser, M., Ford-Hutchinson, A.W., Young, R.N., Chan, C.C. Etoricoxib (MK-0663) preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2, J. Pharmacol. Exp. Ther. 2001, 296, 558-566. 

Riendeau D, Percival D, Brideau C et al. (2001) Etoricoxib (MK-0663) Preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharm Exp Ther 296 558-566... 

Successive molecular modification of our original quinazoline-2-car-boxylic acid led to compounds displaying 5000-fold increases in potency. Several 7,8-dialkoxy substituted pyrimido 4,5-b]quinoline esters are 80 to 400 times as potent as DSCC intravenously, and, more importantly, have potent oral activity in the rat PCA test with ED,o s of 1 mg/kg or less. Comparison with other agents that display oral activity in this test shows that the pyrimido[4,5-b]quinoline series ranks among the most potent orally active inhibitors of mediator release reported to date. 

As mentioned earlier, agent-based modeling and simulation has been widely applied outside the aviation domain, and the state-of-the-art in this area is extensive. A comparison with other (agent-based) dynamic modeling approaches is therefore outside the scope of this article for this purpose, the interested reader is referred to [2, 3],... 

One of the most important applications of diazomethane depends on its ability to replace a mobile hydrogen atom by a methyl group. In comparison with other methylation agents, diazomethane occupies a rather special place this is, in part, because only rather strongly acidic protons are replaced. Because of the simple method of working up the reaction mixture, the reaction is especially well applicable for sensitive compounds and for small amounts. If tautomeric or potentially tautomeric compounds are treated with diazomethane, two... 

Phenol no longer plays any significant role as an antibacterial agent. It is of historical interest, since it was introduced by Lister in 1867 as an antiseptic and has been used as a standard for comparison with other disinfectants, which are then given a phenol coefficient in tests such as the Rideal-Walker test. 

Mercuric chloride at low concentration, in comparison with other metal compounds, induced the least DNA repair [257], despite its demonstrated potency in producing DNA lesions, causing equivalently effective breakage in isolated DNA as well as in DNA from cells previously treated with Hg2 +. The degree of modification in DNA repair induced by mercuric chloride may explain why this agent is not severely mutagenic or carcinogenic [253]. 

Quantitative evaluation of 5-diazouracil against Walker 256 carcinosarcoma, Ehrlich ascites carcinoma, C3H-FX lymphoma and other tumour systems has been studied and detailed results in comparison with other standard active agents have been reported [332]. 

Toxicology. Malathion is an anticholinesterase agent, but it is of a relatively low order of toxicity in comparison with other organophosphates. 

The chapter is divided into 10 parts devoted to individual groups of antimicrobial agents. The text is focused mainly on sample pretreatment, new achievements in method development, comparison with other techniques, and the factors limiting chromatographic analysis. The sample pretreatment and detection conditions (especially for MS detectors) are presented only in the main features, to make the text more concise. 

Birkus G, Hitchcock MJ, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 2002 46 716-23. 

Suitable oxidizing agents include bromine (in benzene) and sulfuryl chloride (in ether/glacial acetic acid). The scope of this method has not yet been fully explored, and appears to be capable of further modification and expansion. Though laborious in comparison with other routes, it makes possible the preparation of certain 1,2-dithiolium salts that cannot be obtained, for example, by the extremely simple Klingsberg method (Section II, A, 2,b). 

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