Combinatorial process

The screening of libraries of compounds for the desired property constitutes an essential part of the combinatorial process. The easier and the faster the screening, the higher the throughput and the more compounds can be screened in a unit of time. This paradigm has led Still s group to develop a combinatorial approach to chiral selectors that involves a visual screening step by optical microscopy that enables the manual selection of the best candidates [81]. 

Each product formed in a given reaction step of a combinatorial process has to be distributed into samples, then react each sample with one of the monomers of the next reaction step. 

The use of combinatorial chemistry for generating libraries to feed in-vitro screens has also become very prevalent over the past decade. This book is silent on that topic since compounds are only included when in a quite advanced developmental stage. Some of the structures that include strings of unlikely moieties suggest that those compounds may have been originally prepared by some combinatorial process. 

Contbinalorial chemistry Using a combinatorial process to prepare sets of compounds from building blocks. 

The initial concept and prachcal use of analytical constructs was designed by Diversity Sciences to facilitate mass-spectral analysis during combinatorial processes [10]. Several internal and external groups adopted the original concept and published similar results [16-20]. Each element of the analyhcal construct developed by Diversity Science is outlined below in more depth in the following sections. 

No. Even when a scent is known to be triggered by a single chemical (like vanilla) there will be an array of receptors that perceive it, and the sensation will be decoded by a combinatorial process. 

Coppola and Daniels (1998) have pointed out that chemical knowledge is extracted from a fully integrated world but then, paradoxically, examined and defined by the dis-integrated world of academe. Isn t it time for us to reintegrate history of chemistry, chemistry, and chemical education That combinatorial process begins here ... 

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