Combinatorial molecular imprinting

Takeuchi, T., Fukuma, D., and Matsui, J., Combinatorial molecular imprinting an approach to synthetic polymer receptors, Anal. Chem., 71, 285, 1999. 

Atrazine MAA 2-sulfoethylaminomethacrylate EDMA CHCI3 Combinatorial molecular imprinting for atrazine-decomposing polymers [177]... 

Takeuchi T, Fukuma D, Matsui J et al. Combinatorial molecular imprinting for formation of atrazine decomposing polymers. Chem Lett 2001 30 530-531. 

To overcome the problem of their limited range of applicability and to extend the spectrum of application other than to the imprint molecule, molecularly imprinted polymer combinatorial libraries for multiple simultaneous chiral separations have been prepared [ 191 ], demonstrating that the ligand cross-reactivities of molecularly imprinted polymers can be beneficially employed for the simultaneous separation of different stereoisomeric structures. 

In another attempt, cyclopeptide SOs and SO libraries, respectively, for CE enan-tioseparations have been developed by combinatorial chemistry approaches [378,379], and recently also molecularly imprinted polymer combinatorial libraries have been prepared [ 191 ]. 

Batch use of imprinted polymers has been applied in the evaluation of polymers by saturation binding tests and in the applications of molecularly imprinted sorbent assays [1,23,24]. In a common procedure, imprinted polymers obtained as blocks were crushed, ground and sieved to prepare sized polymer particles. The resultant particles were then distributed into each vial and recovered by filtration after use. Recently, a new batch-type in situ procedure has been reported. It utilises a polymer coating prepared on an inner surface at the bottom of a vial and allows direct assessment of the polymers. In this section, this type of in situ preparation of imprinted polymers and an application to combinatorial chemistry are described. 

The availability of various functional monomers is essential to operate molecular imprinting by a combinatorial method. Therefore, efforts to design and synthesise novel functional monomers have been made for developing a desired specificity and functions [2,3, 27]. With a wide selection of functional monomers, further functionalised polymers, such as catalysts and sensor materials, will also be developed by the combinatorial chemistry-based molecular imprinting. 

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